A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination associated with cystic fibrosis.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c |
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oai:doaj.org-article:1010cb2b07ac42418e6fb9795f6fb27c2021-12-02T17:01:29ZA small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion10.1038/s41467-021-24575-x2041-1723https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24575-xhttps://doaj.org/toc/2041-1723Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination associated with cystic fibrosis.Jyoti SharmaMing DuEric WongVenkateshwar MutyamYao LiJianguo ChenJamie WangenKari ThrasherLianwu FuNing PengLiping TangKaimao LiuBini MathewRobert J. BostwickCorinne E. Augelli-SzafranHermann BihlerFeng LiangJerome MahiouJosef SaltzAndras RabJeong HongEric J. SorscherEric M. MendenhallCandice J. CoppolaKim M. KeelingRachel GreenMartin MenseMark J. SutoSteven M. RoweDavid M. BedwellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jyoti Sharma Ming Du Eric Wong Venkateshwar Mutyam Yao Li Jianguo Chen Jamie Wangen Kari Thrasher Lianwu Fu Ning Peng Liping Tang Kaimao Liu Bini Mathew Robert J. Bostwick Corinne E. Augelli-Szafran Hermann Bihler Feng Liang Jerome Mahiou Josef Saltz Andras Rab Jeong Hong Eric J. Sorscher Eric M. Mendenhall Candice J. Coppola Kim M. Keeling Rachel Green Martin Mense Mark J. Suto Steven M. Rowe David M. Bedwell A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion |
| description |
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination associated with cystic fibrosis. |
| format |
article |
| author |
Jyoti Sharma Ming Du Eric Wong Venkateshwar Mutyam Yao Li Jianguo Chen Jamie Wangen Kari Thrasher Lianwu Fu Ning Peng Liping Tang Kaimao Liu Bini Mathew Robert J. Bostwick Corinne E. Augelli-Szafran Hermann Bihler Feng Liang Jerome Mahiou Josef Saltz Andras Rab Jeong Hong Eric J. Sorscher Eric M. Mendenhall Candice J. Coppola Kim M. Keeling Rachel Green Martin Mense Mark J. Suto Steven M. Rowe David M. Bedwell |
| author_facet |
Jyoti Sharma Ming Du Eric Wong Venkateshwar Mutyam Yao Li Jianguo Chen Jamie Wangen Kari Thrasher Lianwu Fu Ning Peng Liping Tang Kaimao Liu Bini Mathew Robert J. Bostwick Corinne E. Augelli-Szafran Hermann Bihler Feng Liang Jerome Mahiou Josef Saltz Andras Rab Jeong Hong Eric J. Sorscher Eric M. Mendenhall Candice J. Coppola Kim M. Keeling Rachel Green Martin Mense Mark J. Suto Steven M. Rowe David M. Bedwell |
| author_sort |
Jyoti Sharma |
| title |
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion |
| title_short |
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion |
| title_full |
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion |
| title_fullStr |
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion |
| title_full_unstemmed |
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion |
| title_sort |
small molecule that induces translational readthrough of cftr nonsense mutations by erf1 depletion |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c |
| work_keys_str_mv |
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