Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion

CH Loo,1,2 M Basri,2 R Ismail,1 HLN Lau,1 BA Tejo,2 MS Kanthimathi,3 HA Hassan,1 YM Choo11Malaysian Palm Oil Board, Bandar Baru Bangi, 2Department of Chemistry, Universiti Putra Malaysia, Serdang, 3Department of Molecular Medicine, University of Malaya, Kuala Lumpur, MalaysiaPurpose: To study the ef...

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Autores principales:	Loo CH, Basri M, Ismail R, Lau HL, Tejo BA, Kanthimathi MS, Hassan HA, Choo YM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/10118cdd50864345a321ac1fffedca71
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spelling	oai:doaj.org-article:10118cdd50864345a321ac1fffedca712021-12-02T02:49:27ZEffect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion1176-91141178-2013https://doaj.org/article/10118cdd50864345a321ac1fffedca712012-12-01T00:00:00Zhttp://www.dovepress.com/effect-of-compositions-in-nanostructured-lipid-carriers-nlc-on-skin-hy-a11818https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013CH Loo,1,2 M Basri,2 R Ismail,1 HLN Lau,1 BA Tejo,2 MS Kanthimathi,3 HA Hassan,1 YM Choo11Malaysian Palm Oil Board, Bandar Baru Bangi, 2Department of Chemistry, Universiti Putra Malaysia, Serdang, 3Department of Molecular Medicine, University of Malaya, Kuala Lumpur, MalaysiaPurpose: To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss.Methods: The various NLC formulations (A1&ndash;A5) were prepared and their particle size, zeta potential, viscosity, and stability were analyzed. The formulations were applied on the forearms of the 20 female volunteers (one forearm of each volunteer was left untreated as a control). The subjects stayed for 30 minutes in a conditioned room with their forearms uncovered to let the skin adapt to the temperature (22&deg;C &plusmn; 2&deg;C) and humidity (50% &plusmn; 2%) of the room. Skin hydration and skin occlusion were recorded at day one (before treatment) and day seven (after treatment). Three measurements for skin hydration and skin occlusion were performed in each testing area.Results: NLC formulations with the highest lipid concentration, highest solid lipid concentration, and additional propylene glycol (formulations A1, A2, and A5) showed higher physical stability than other formulations. The addition of propylene glycol into an NLC system helped to reduce the particle size of the NLC and enhanced its long-term physical stability. All the NLC formulations were found to significantly increase skin hydration compared to the untreated controls within 7 days. All NLC formulations exhibited occlusive properties as they reduced the transepidermal water loss within 7 days. This effect was more pronounced with the addition of propylene glycol or lecithin into an NLC formulation, whereby at least 60% reduction in transepidermal water loss was observed.Conclusion: NLCs with high lipid content, solid lipid content, phospholipid, and lecithin are a highly effective cosmetic delivery system for cosmetic topical applications that are designed to boost skin hydration.Keywords: nanostructured lipid carriers, transepidermal water loss, skin hydration, particle sizeLoo CHBasri MIsmail RLau HLTejo BAKanthimathi MSHassan HAChoo YMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 13-22 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Loo CH Basri M Ismail R Lau HL Tejo BA Kanthimathi MS Hassan HA Choo YM Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion
description	CH Loo,1,2 M Basri,2 R Ismail,1 HLN Lau,1 BA Tejo,2 MS Kanthimathi,3 HA Hassan,1 YM Choo11Malaysian Palm Oil Board, Bandar Baru Bangi, 2Department of Chemistry, Universiti Putra Malaysia, Serdang, 3Department of Molecular Medicine, University of Malaya, Kuala Lumpur, MalaysiaPurpose: To study the effects of varying lipid concentrations, lipid and oil ratio, and the addition of propylene glycol and lecithin on the long-term physical stability of nanostructured lipid nanocarriers (NLC), skin hydration, and transepidermal water loss.Methods: The various NLC formulations (A1&ndash;A5) were prepared and their particle size, zeta potential, viscosity, and stability were analyzed. The formulations were applied on the forearms of the 20 female volunteers (one forearm of each volunteer was left untreated as a control). The subjects stayed for 30 minutes in a conditioned room with their forearms uncovered to let the skin adapt to the temperature (22&deg;C &plusmn; 2&deg;C) and humidity (50% &plusmn; 2%) of the room. Skin hydration and skin occlusion were recorded at day one (before treatment) and day seven (after treatment). Three measurements for skin hydration and skin occlusion were performed in each testing area.Results: NLC formulations with the highest lipid concentration, highest solid lipid concentration, and additional propylene glycol (formulations A1, A2, and A5) showed higher physical stability than other formulations. The addition of propylene glycol into an NLC system helped to reduce the particle size of the NLC and enhanced its long-term physical stability. All the NLC formulations were found to significantly increase skin hydration compared to the untreated controls within 7 days. All NLC formulations exhibited occlusive properties as they reduced the transepidermal water loss within 7 days. This effect was more pronounced with the addition of propylene glycol or lecithin into an NLC formulation, whereby at least 60% reduction in transepidermal water loss was observed.Conclusion: NLCs with high lipid content, solid lipid content, phospholipid, and lecithin are a highly effective cosmetic delivery system for cosmetic topical applications that are designed to boost skin hydration.Keywords: nanostructured lipid carriers, transepidermal water loss, skin hydration, particle size
format	article
author	Loo CH Basri M Ismail R Lau HL Tejo BA Kanthimathi MS Hassan HA Choo YM
author_facet	Loo CH Basri M Ismail R Lau HL Tejo BA Kanthimathi MS Hassan HA Choo YM
author_sort	Loo CH
title	Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion
title_short	Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion
title_full	Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion
title_fullStr	Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion
title_full_unstemmed	Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion
title_sort	effect of compositions in nanostructured lipid carriers (nlc) on skin hydration and occlusion
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/10118cdd50864345a321ac1fffedca71
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Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion

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