Thrombophilic screening in retinal artery occlusion patients

Thrombophilic screening in retinal artery occlusion patients

Valeria Nagy1, Lili Takacs1, Zita Steiber1, György Pfliegler2, Andras Berta11Department of Ophthalmology, 2Division of Rare Diseases, University of Debrecen Medical and Health Science Center, Debrecen, HungaryBackground: Retinal artery occlusion (RAO) is an ischemic vascular damage of t...

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Autores principales: Valeria Nagy, Lili Takacs, Zita Steiber, György Pfliegler, Andras Berta
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2008
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/10144606a944411cb7b86f3ca96a77a5
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spelling oai:doaj.org-article:10144606a944411cb7b86f3ca96a77a52021-12-02T07:04:48ZThrombophilic screening in retinal artery occlusion patients1177-54671177-5483https://doaj.org/article/10144606a944411cb7b86f3ca96a77a52008-10-01T00:00:00Zhttp://www.dovepress.com/thrombophilic-screening-in-retinal-artery-occlusion-patients-a2360https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Valeria Nagy1, Lili Takacs1, Zita Steiber1, György Pfliegler2, Andras Berta11Department of Ophthalmology, 2Division of Rare Diseases, University of Debrecen Medical and Health Science Center, Debrecen, HungaryBackground: Retinal artery occlusion (RAO) is an ischemic vascular damage of the retina, which frequently leads to sudden, mostly irreversible loss of vision. In this study, blood thrombophilic factors as well as cardiovascular risk factors were investigated for their relevance to this pathology. Thrombophilic risk factors so far not evaluated were included in the study.Patients and methods: 28 RAO patients and 81 matched control subjects were examined. From blood samples, protein C, protein S, antithrombinopathy, and factor V (Leiden) mutation (FV), factor II gene polymorphism, factor VIII C level, plasminogen activity, lipoprotein(a) and fibrinogen levels, hyperhomocysteinemia and presence of anticardiolipin – antiphospholipid antibodies were investigated. Possibly relevant pathologies such as diabetes mellitus, hypertension, and ischemic heart disease were also registered. Statistical analysis by logistic regression was performed with 95% confidence intervals.Results: In the group of patients with RAO only the incidence of hypertension (OR: 3.33, 95% CI: 1.30–9.70, p = 0.014) as an average risk factor showed significant difference, but thrombophilic factors such as hyperfibrinogenemia (OR: 2.9, 95% CI: 1.29–6.57, p = 0.010) and the presence of FV (Leiden mutation) (OR: 3.9, 95% CI: 1.43–10.96, p = 0.008) increased the chances of developing this disease.Conclusions: Our results support the assumption that thrombophilia may contribute to the development of RAO besides vascular damage due to the presence of cardiovascular risk factors. Further studies are needed, however, to justify the possible use of secondary prophylaxis in form of anticoagulant/antiplatelet therapy.Keywords: retinal arterial occlusion, risk factors, thrombophilia Valeria NagyLili TakacsZita SteiberGyörgy PflieglerAndras BertaDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 3, Pp 557-561 (2008)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Valeria Nagy
Lili Takacs
Zita Steiber
György Pfliegler
Andras Berta
Thrombophilic screening in retinal artery occlusion patients
description Valeria Nagy1, Lili Takacs1, Zita Steiber1, György Pfliegler2, Andras Berta11Department of Ophthalmology, 2Division of Rare Diseases, University of Debrecen Medical and Health Science Center, Debrecen, HungaryBackground: Retinal artery occlusion (RAO) is an ischemic vascular damage of the retina, which frequently leads to sudden, mostly irreversible loss of vision. In this study, blood thrombophilic factors as well as cardiovascular risk factors were investigated for their relevance to this pathology. Thrombophilic risk factors so far not evaluated were included in the study.Patients and methods: 28 RAO patients and 81 matched control subjects were examined. From blood samples, protein C, protein S, antithrombinopathy, and factor V (Leiden) mutation (FV), factor II gene polymorphism, factor VIII C level, plasminogen activity, lipoprotein(a) and fibrinogen levels, hyperhomocysteinemia and presence of anticardiolipin – antiphospholipid antibodies were investigated. Possibly relevant pathologies such as diabetes mellitus, hypertension, and ischemic heart disease were also registered. Statistical analysis by logistic regression was performed with 95% confidence intervals.Results: In the group of patients with RAO only the incidence of hypertension (OR: 3.33, 95% CI: 1.30–9.70, p = 0.014) as an average risk factor showed significant difference, but thrombophilic factors such as hyperfibrinogenemia (OR: 2.9, 95% CI: 1.29–6.57, p = 0.010) and the presence of FV (Leiden mutation) (OR: 3.9, 95% CI: 1.43–10.96, p = 0.008) increased the chances of developing this disease.Conclusions: Our results support the assumption that thrombophilia may contribute to the development of RAO besides vascular damage due to the presence of cardiovascular risk factors. Further studies are needed, however, to justify the possible use of secondary prophylaxis in form of anticoagulant/antiplatelet therapy.Keywords: retinal arterial occlusion, risk factors, thrombophilia
format article
author Valeria Nagy
Lili Takacs
Zita Steiber
György Pfliegler
Andras Berta
author_facet Valeria Nagy
Lili Takacs
Zita Steiber
György Pfliegler
Andras Berta
author_sort Valeria Nagy
title Thrombophilic screening in retinal artery occlusion patients
title_short Thrombophilic screening in retinal artery occlusion patients
title_full Thrombophilic screening in retinal artery occlusion patients
title_fullStr Thrombophilic screening in retinal artery occlusion patients
title_full_unstemmed Thrombophilic screening in retinal artery occlusion patients
title_sort thrombophilic screening in retinal artery occlusion patients
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/10144606a944411cb7b86f3ca96a77a5
work_keys_str_mv AT valerianagy thrombophilicscreeninginretinalarteryocclusionpatients
AT lilitakacs thrombophilicscreeninginretinalarteryocclusionpatients
AT zitasteiber thrombophilicscreeninginretinalarteryocclusionpatients
AT gyampoumlrgypfliegler thrombophilicscreeninginretinalarteryocclusionpatients
AT andrasberta thrombophilicscreeninginretinalarteryocclusionpatients
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