Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis

Ye Ji Ahn1,2 Tae Hoon Kong1,2 Jin Sil Choi1,2 Wan Su Yun,3 Jaehong Key,3 Young Joon Seo1,21Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, South Korea; 2Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, South Korea;...

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Autores principales:	Ahn YJ, Kong TH, Choi JS, Yun WS, Key J, Seo YJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Stem cells homing SPION Magnetic attraction stem cell therapy Systematic review Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/10170979c0d149199f2fac3eedeca7de
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spelling	oai:doaj.org-article:10170979c0d149199f2fac3eedeca7de2021-12-02T03:06:23ZStrategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis1178-2013https://doaj.org/article/10170979c0d149199f2fac3eedeca7de2019-07-01T00:00:00Zhttps://www.dovepress.com/strategies-to-enhance-efficacy-of-spion-labeled-stem-cell-homing-by-ma-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ye Ji Ahn1,2 Tae Hoon Kong1,2 Jin Sil Choi1,2 Wan Su Yun,3 Jaehong Key,3 Young Joon Seo1,21Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, South Korea; 2Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, South Korea; 3Department of Biomedical Engineering, Yonsei University, Wonju, South KoreaAbstract: Stem cells possess a promising potential in the clinical field. The application and effective delivery of stem cells to the desired target organ or site of injury plays an important role. This review describes strategies on understanding the effective delivery of stem cells labeled with superparamagnetic iron oxide nanoparticles (SPION) using an external magnet to enhance stem cell migration in vivo and in vitro. Fourteen total publications among 174 articles were selected. Stem cell type, SPION characteristics, labeling time, and magnetic force in vivo are considered important factors affecting the effective delivery of stem cells to the homing site. Most papers reported that the efficiency was increased when magnet is applied compared to those without. Ten studies analyzed the homing competency of SPION-labeled MSCs in vitro by observing the migration of the cell toward the external magnet. In cell-based experiments, the mechanism of magnetic attraction, the kind of nanoparticles, and various stem cells were studied well. Meta-analysis has shown the mean size of nanoparticles and degree of recovery or regeneration of damaged target organs upon in vivo studies. This strategy may provide a guideline for designing studies involving stem cell homing and further expand stem cell.Keywords: stem cells, homing, SPION, magnetic attraction, stem cell therapy, systematic reviewAhn YJKong THChoi JSYun WSKey JSeo YJDove Medical PressarticleStem cellshomingSPIONMagnetic attractionstem cell therapySystematic reviewMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4849-4866 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Stem cells homing SPION Magnetic attraction stem cell therapy Systematic review Medicine (General) R5-920
spellingShingle	Stem cells homing SPION Magnetic attraction stem cell therapy Systematic review Medicine (General) R5-920 Ahn YJ Kong TH Choi JS Yun WS Key J Seo YJ Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
description	Ye Ji Ahn1,2 Tae Hoon Kong1,2 Jin Sil Choi1,2 Wan Su Yun,3 Jaehong Key,3 Young Joon Seo1,21Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, South Korea; 2Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, South Korea; 3Department of Biomedical Engineering, Yonsei University, Wonju, South KoreaAbstract: Stem cells possess a promising potential in the clinical field. The application and effective delivery of stem cells to the desired target organ or site of injury plays an important role. This review describes strategies on understanding the effective delivery of stem cells labeled with superparamagnetic iron oxide nanoparticles (SPION) using an external magnet to enhance stem cell migration in vivo and in vitro. Fourteen total publications among 174 articles were selected. Stem cell type, SPION characteristics, labeling time, and magnetic force in vivo are considered important factors affecting the effective delivery of stem cells to the homing site. Most papers reported that the efficiency was increased when magnet is applied compared to those without. Ten studies analyzed the homing competency of SPION-labeled MSCs in vitro by observing the migration of the cell toward the external magnet. In cell-based experiments, the mechanism of magnetic attraction, the kind of nanoparticles, and various stem cells were studied well. Meta-analysis has shown the mean size of nanoparticles and degree of recovery or regeneration of damaged target organs upon in vivo studies. This strategy may provide a guideline for designing studies involving stem cell homing and further expand stem cell.Keywords: stem cells, homing, SPION, magnetic attraction, stem cell therapy, systematic review
format	article
author	Ahn YJ Kong TH Choi JS Yun WS Key J Seo YJ
author_facet	Ahn YJ Kong TH Choi JS Yun WS Key J Seo YJ
author_sort	Ahn YJ
title	Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
title_short	Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
title_full	Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
title_fullStr	Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
title_full_unstemmed	Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
title_sort	strategies to enhance efficacy of spion-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/10170979c0d149199f2fac3eedeca7de
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Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis

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