Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review

Carlos-Alberto Calderon-Ospina,1,* Mauricio Orlando Nava-Mesa,2,* Ana María Paez-Hurtado2 1Center for Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; 2Neuroscience Research G...

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Autores principales:	Calderon-Ospina CA, Nava-Mesa MO, Paez-Hurtado AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	neurotropic b vitamins safety thiamine pyridoxine cobalamin neurotoxicity hip fracture lung cancer. Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1018e224c1ac48f3ac2103847691d217
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spelling	oai:doaj.org-article:1018e224c1ac48f3ac2103847691d2172021-12-02T13:46:22ZUpdate on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review1178-203Xhttps://doaj.org/article/1018e224c1ac48f3ac2103847691d2172020-12-01T00:00:00Zhttps://www.dovepress.com/update-on-safety-profiles-of-vitamins-b1-b6-and-b12-a-narrative-review-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XCarlos-Alberto Calderon-Ospina,1,* Mauricio Orlando Nava-Mesa,2,* Ana María Paez-Hurtado2 1Center for Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; 2Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia*These authors contributed equally to this workCorrespondence: Carlos-Alberto Calderon-OspinaSchool of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63C– 69, Bogota, DC, ColombiaTel +571-2970200 Ext 3318Fax +571-2818583Email carlos.calderon@urosario.edu.coAbstract: The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.Keywords: neurotropic B vitamins, safety, thiamine, pyridoxine, cobalamin, neurotoxicity, hip fracture, lung cancerCalderon-Ospina CANava-Mesa MOPaez-Hurtado AMDove Medical Pressarticleneurotropic b vitaminssafetythiaminepyridoxinecobalaminneurotoxicityhip fracturelung cancer.Therapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 1275-1288 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurotropic b vitamins safety thiamine pyridoxine cobalamin neurotoxicity hip fracture lung cancer. Therapeutics. Pharmacology RM1-950
spellingShingle	neurotropic b vitamins safety thiamine pyridoxine cobalamin neurotoxicity hip fracture lung cancer. Therapeutics. Pharmacology RM1-950 Calderon-Ospina CA Nava-Mesa MO Paez-Hurtado AM Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review
description	Carlos-Alberto Calderon-Ospina,1,* Mauricio Orlando Nava-Mesa,2,* Ana María Paez-Hurtado2 1Center for Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia; 2Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia*These authors contributed equally to this workCorrespondence: Carlos-Alberto Calderon-OspinaSchool of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63C– 69, Bogota, DC, ColombiaTel +571-2970200 Ext 3318Fax +571-2818583Email carlos.calderon@urosario.edu.coAbstract: The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations (eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development. Because it warrants continued consideration, we also provide an update on neurotoxicity associated with vitamin B6. We consider that neurological side effects due to vitamin B6 intake are rare and only occur with high daily doses and/or longer treatment duration. The benefit-risk ratio of high-dose treatment with neurotropic B vitamins in indications like PN is therefore considered advantageous, particularly if dosing recommendations are followed and serum levels monitored.Keywords: neurotropic B vitamins, safety, thiamine, pyridoxine, cobalamin, neurotoxicity, hip fracture, lung cancer
format	article
author	Calderon-Ospina CA Nava-Mesa MO Paez-Hurtado AM
author_facet	Calderon-Ospina CA Nava-Mesa MO Paez-Hurtado AM
author_sort	Calderon-Ospina CA
title	Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review
title_short	Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review
title_full	Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review
title_fullStr	Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review
title_full_unstemmed	Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review
title_sort	update on safety profiles of vitamins b1, b6, and b12: a narrative review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1018e224c1ac48f3ac2103847691d217
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Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review

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