Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

Specific cancer cell vulnerabilities can provide an opportunity for the development of novel cancer therapeutics. In this study the authors demonstrate that targeting ADAR1 represents a potential therapeutic vulnerability in cancers with activated interferon response signatures.

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Autores principales:	Hugh S. Gannon, Tao Zou, Michael K. Kiessling, Galen F. Gao, Diana Cai, Peter S. Choi, Alexandru P. Ivan, Ilana Buchumenski, Ashton C. Berger, Jonathan T. Goldstein, Andrew D. Cherniack, Francisca Vazquez, Aviad Tsherniak, Erez Y. Levanon, William C. Hahn, Matthew Meyerson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/101c1efd608349f2b4bd50157c1c3989
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spelling	oai:doaj.org-article:101c1efd608349f2b4bd50157c1c39892021-12-02T14:38:53ZIdentification of ADAR1 adenosine deaminase dependency in a subset of cancer cells10.1038/s41467-018-07824-42041-1723https://doaj.org/article/101c1efd608349f2b4bd50157c1c39892018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07824-4https://doaj.org/toc/2041-1723Specific cancer cell vulnerabilities can provide an opportunity for the development of novel cancer therapeutics. In this study the authors demonstrate that targeting ADAR1 represents a potential therapeutic vulnerability in cancers with activated interferon response signatures.Hugh S. GannonTao ZouMichael K. KiesslingGalen F. GaoDiana CaiPeter S. ChoiAlexandru P. IvanIlana BuchumenskiAshton C. BergerJonathan T. GoldsteinAndrew D. CherniackFrancisca VazquezAviad TsherniakErez Y. LevanonWilliam C. HahnMatthew MeyersonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hugh S. Gannon Tao Zou Michael K. Kiessling Galen F. Gao Diana Cai Peter S. Choi Alexandru P. Ivan Ilana Buchumenski Ashton C. Berger Jonathan T. Goldstein Andrew D. Cherniack Francisca Vazquez Aviad Tsherniak Erez Y. Levanon William C. Hahn Matthew Meyerson Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
description	Specific cancer cell vulnerabilities can provide an opportunity for the development of novel cancer therapeutics. In this study the authors demonstrate that targeting ADAR1 represents a potential therapeutic vulnerability in cancers with activated interferon response signatures.
format	article
author	Hugh S. Gannon Tao Zou Michael K. Kiessling Galen F. Gao Diana Cai Peter S. Choi Alexandru P. Ivan Ilana Buchumenski Ashton C. Berger Jonathan T. Goldstein Andrew D. Cherniack Francisca Vazquez Aviad Tsherniak Erez Y. Levanon William C. Hahn Matthew Meyerson
author_facet	Hugh S. Gannon Tao Zou Michael K. Kiessling Galen F. Gao Diana Cai Peter S. Choi Alexandru P. Ivan Ilana Buchumenski Ashton C. Berger Jonathan T. Goldstein Andrew D. Cherniack Francisca Vazquez Aviad Tsherniak Erez Y. Levanon William C. Hahn Matthew Meyerson
author_sort	Hugh S. Gannon
title	Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
title_short	Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
title_full	Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
title_fullStr	Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
title_full_unstemmed	Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
title_sort	identification of adar1 adenosine deaminase dependency in a subset of cancer cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/101c1efd608349f2b4bd50157c1c3989
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Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

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