The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis

Abstract This meta-analysis was undertaken to investigate the relationship between hematological indices and autoimmune rheumatic diseases (ARDs). PubMed, Embase, and Web of Science were searchedfor studies of ARDs and hematological indices. Standardized mean difference (SMD) was calculated with con...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuanyu Hao, Dongyang Li, Dan Wu, Ning Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/101c61d9755d465f8bbecfc8fe1bab15
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:101c61d9755d465f8bbecfc8fe1bab15
record_format	dspace
spelling	oai:doaj.org-article:101c61d9755d465f8bbecfc8fe1bab152021-12-02T15:05:44ZThe Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis10.1038/s41598-017-11398-42045-2322https://doaj.org/article/101c61d9755d465f8bbecfc8fe1bab152017-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-11398-4https://doaj.org/toc/2045-2322Abstract This meta-analysis was undertaken to investigate the relationship between hematological indices and autoimmune rheumatic diseases (ARDs). PubMed, Embase, and Web of Science were searchedfor studies of ARDs and hematological indices. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. 18 studies were included in our meta-analysis. Compared to the healthy control group, neutrophil–lymphocyte ratio (NLR) was increased in patients with ankylosing spongdylitis(AS), Behçet’s disease(BD), andrheumatoid arthritis(RA)(SMD = 0.33; 95% CI: 0.19 to 0.47; SMD = 1.90; 95% CI: 0.13 to 3.67; SMD = 0.75; 95% CI: 0.23 to 1.28). Platelet–lymphocyte ratio (PLR) was found increased in RA and SLE (SMD = 33.91; 95% CI: 20.50 to 47.32; SMD = 59.11; 95% CI: 4.46 to 113.76). Mean platelet volume (MPV)was irrelevant to BD and SLE by comparing with the healthy control group respectively. (SMD = 0.24; 95% CI: −0.49 to 0.97; SMD = −0.15; 95% CI: −1.77 to 1.48). Red cell distribution width (RDW) was not related to AS (SMD = 0.59, 95% CI: −0.37, 1.55). Our findings indicated that NLR had a strong association with AS, BD, and RA. PLR was also related to RA and SLE. NLR and PLR could be recommended as inexpensive diagnostic biomarkers for ARDs.Xuanyu HaoDongyang LiDan WuNing ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xuanyu Hao Dongyang Li Dan Wu Ning Zhang The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis
description	Abstract This meta-analysis was undertaken to investigate the relationship between hematological indices and autoimmune rheumatic diseases (ARDs). PubMed, Embase, and Web of Science were searchedfor studies of ARDs and hematological indices. Standardized mean difference (SMD) was calculated with confidence interval (CI) of 95%. 18 studies were included in our meta-analysis. Compared to the healthy control group, neutrophil–lymphocyte ratio (NLR) was increased in patients with ankylosing spongdylitis(AS), Behçet’s disease(BD), andrheumatoid arthritis(RA)(SMD = 0.33; 95% CI: 0.19 to 0.47; SMD = 1.90; 95% CI: 0.13 to 3.67; SMD = 0.75; 95% CI: 0.23 to 1.28). Platelet–lymphocyte ratio (PLR) was found increased in RA and SLE (SMD = 33.91; 95% CI: 20.50 to 47.32; SMD = 59.11; 95% CI: 4.46 to 113.76). Mean platelet volume (MPV)was irrelevant to BD and SLE by comparing with the healthy control group respectively. (SMD = 0.24; 95% CI: −0.49 to 0.97; SMD = −0.15; 95% CI: −1.77 to 1.48). Red cell distribution width (RDW) was not related to AS (SMD = 0.59, 95% CI: −0.37, 1.55). Our findings indicated that NLR had a strong association with AS, BD, and RA. PLR was also related to RA and SLE. NLR and PLR could be recommended as inexpensive diagnostic biomarkers for ARDs.
format	article
author	Xuanyu Hao Dongyang Li Dan Wu Ning Zhang
author_facet	Xuanyu Hao Dongyang Li Dan Wu Ning Zhang
author_sort	Xuanyu Hao
title	The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis
title_short	The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis
title_full	The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis
title_fullStr	The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis
title_full_unstemmed	The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis
title_sort	relationship between hematological indices and autoimmune rheumatic diseases (ards), a meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/101c61d9755d465f8bbecfc8fe1bab15
work_keys_str_mv	AT xuanyuhao therelationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT dongyangli therelationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT danwu therelationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT ningzhang therelationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT xuanyuhao relationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT dongyangli relationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT danwu relationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis AT ningzhang relationshipbetweenhematologicalindicesandautoimmunerheumaticdiseasesardsametaanalysis
_version_	1718388688489021440

The Relationship between Hematological Indices and Autoimmune Rheumatic Diseases (ARDs), a Meta-Analysis

Ejemplares similares