Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation

The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases o...

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Autor principal:	Daria Jadreškić
Formato:	article
Lenguaje:	EN
Publicado:	University of Rijeka. Faculty of Humanities and Social Sciences 2021
Materias:	adaptive clinical trials randomized controlled trials reliability urgency precision medicine translational medicine Philosophy (General) B1-5802
Acceso en línea:	https://doaj.org/article/101d00c73dd149d1b4e5b708f03d9896
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spelling	oai:doaj.org-article:101d00c73dd149d1b4e5b708f03d98962021-11-26T22:21:46ZAdapt to Translate – Adaptive Clinical Trials and Biomedical Innovation1845-84751849-0514https://doaj.org/article/101d00c73dd149d1b4e5b708f03d98962021-01-01T00:00:00Zhttps://hrcak.srce.hr/file/386125https://doaj.org/toc/1845-8475https://doaj.org/toc/1849-0514The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. The development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements.Daria JadreškićUniversity of Rijeka. Faculty of Humanities and Social Sciences articleadaptive clinical trialsrandomized controlled trialsreliabilityurgencyprecision medicinetranslational medicinePhilosophy (General)B1-5802ENEuropean Journal of Analytic Philosophy, Vol 17, Iss 2, Pp S3-24 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adaptive clinical trials randomized controlled trials reliability urgency precision medicine translational medicine Philosophy (General) B1-5802
spellingShingle	adaptive clinical trials randomized controlled trials reliability urgency precision medicine translational medicine Philosophy (General) B1-5802 Daria Jadreškić Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation
description	The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. The development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements.
format	article
author	Daria Jadreškić
author_facet	Daria Jadreškić
author_sort	Daria Jadreškić
title	Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation
title_short	Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation
title_full	Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation
title_fullStr	Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation
title_full_unstemmed	Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation
title_sort	adapt to translate – adaptive clinical trials and biomedical innovation
publisher	University of Rijeka. Faculty of Humanities and Social Sciences
publishDate	2021
url	https://doaj.org/article/101d00c73dd149d1b4e5b708f03d9896
work_keys_str_mv	AT dariajadreskic adapttotranslateadaptiveclinicaltrialsandbiomedicalinnovation
_version_	1718409211495317504

Adapt to Translate – Adaptive Clinical Trials and Biomedical Innovation

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