Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse b...

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Autores principales:	Hoe-Yune Jung, Dongyeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go, Namgyu Lee, Dohyun Lee, Heehwa G. Son, Jongsu Jeon, Seong-Hoon Kim, Jong Hyuk Yoon, Seon-Min Park, Seung-Jae V. Lee, In-Kyu Lee, Kwan Yong Choi, Sung Ho Ryu, Kazunari Nohara, Seung-Hee Yoo, Zheng Chen, Kyong-Tai Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10201d00788242438ead92d92999e6dd
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spelling	oai:doaj.org-article:10201d00788242438ead92d92999e6dd2021-12-02T12:30:51ZMyricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α10.1038/s41598-017-05303-22045-2322https://doaj.org/article/10201d00788242438ead92d92999e6dd2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05303-2https://doaj.org/toc/2045-2322Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1α acetylation through SIRT1 activation. Furthermore, myricetin significantly improved the healthspan and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans. These results demonstrate that myricetin enhances mitochondrial activity, possibly by activating PGC-1α and SIRT1, to improve physical endurance, strongly suggesting myricetin as a mitochondria-activating agent.Hoe-Yune JungDongyeop LeeHye Guk RyuBo-Hwa ChoiYounghoon GoNamgyu LeeDohyun LeeHeehwa G. SonJongsu JeonSeong-Hoon KimJong Hyuk YoonSeon-Min ParkSeung-Jae V. LeeIn-Kyu LeeKwan Yong ChoiSung Ho RyuKazunari NoharaSeung-Hee YooZheng ChenKyong-Tai KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hoe-Yune Jung Dongyeop Lee Hye Guk Ryu Bo-Hwa Choi Younghoon Go Namgyu Lee Dohyun Lee Heehwa G. Son Jongsu Jeon Seong-Hoon Kim Jong Hyuk Yoon Seon-Min Park Seung-Jae V. Lee In-Kyu Lee Kwan Yong Choi Sung Ho Ryu Kazunari Nohara Seung-Hee Yoo Zheng Chen Kyong-Tai Kim Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
description	Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1α acetylation through SIRT1 activation. Furthermore, myricetin significantly improved the healthspan and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans. These results demonstrate that myricetin enhances mitochondrial activity, possibly by activating PGC-1α and SIRT1, to improve physical endurance, strongly suggesting myricetin as a mitochondria-activating agent.
format	article
author	Hoe-Yune Jung Dongyeop Lee Hye Guk Ryu Bo-Hwa Choi Younghoon Go Namgyu Lee Dohyun Lee Heehwa G. Son Jongsu Jeon Seong-Hoon Kim Jong Hyuk Yoon Seon-Min Park Seung-Jae V. Lee In-Kyu Lee Kwan Yong Choi Sung Ho Ryu Kazunari Nohara Seung-Hee Yoo Zheng Chen Kyong-Tai Kim
author_facet	Hoe-Yune Jung Dongyeop Lee Hye Guk Ryu Bo-Hwa Choi Younghoon Go Namgyu Lee Dohyun Lee Heehwa G. Son Jongsu Jeon Seong-Hoon Kim Jong Hyuk Yoon Seon-Min Park Seung-Jae V. Lee In-Kyu Lee Kwan Yong Choi Sung Ho Ryu Kazunari Nohara Seung-Hee Yoo Zheng Chen Kyong-Tai Kim
author_sort	Hoe-Yune Jung
title	Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
title_short	Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
title_full	Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
title_fullStr	Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
title_full_unstemmed	Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
title_sort	myricetin improves endurance capacity and mitochondrial density by activating sirt1 and pgc-1α
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10201d00788242438ead92d92999e6dd
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Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

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