Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra

The estrus cycle of bitches is divided into four phases: proestrus, estrus, diestrus and anestrus, during which different morphological changes, and also cyclic changes of estrogen and progesterone receptors are present. Several pathological changes can be differentiated on the endometrium, but one...

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Autores principales:	Marinković Darko, Aničić Milan, Vakanjac Slobodanka, Nedić Svetlana, Magaš Vladimir
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	bitches uterus cystic endometrial hyperplasia pyometra estrogen receptors progesterone receptors Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/10216dae8dd1403db6769bc843b516f0
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spelling	oai:doaj.org-article:10216dae8dd1403db6769bc843b516f02021-11-17T21:27:52ZMorphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra1820-744810.2478/acve-2018-0021https://doaj.org/article/10216dae8dd1403db6769bc843b516f02018-09-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0021https://doaj.org/toc/1820-7448The estrus cycle of bitches is divided into four phases: proestrus, estrus, diestrus and anestrus, during which different morphological changes, and also cyclic changes of estrogen and progesterone receptors are present. Several pathological changes can be differentiated on the endometrium, but one of these is the most important - cystic endometrial hyperplasia, which frequently develops into pyometra. The aim of the present study was to describe morphological characteristics, and expression of estrogen and progesterone receptors on the endometrium of mixedbreed bitches during the different phases of the estrus cycle, cystic endometrial hyperplasia and pyometra. The uterus and ovaries of 36 mixed breed bitches in different phases of the estrus cycle and also with cystic endometrial hyperplasia (CEH) and chronic purulent endometritis - pyometra were examined macroscopically, histopathologically, and immunohistochemically for estrogen receptors (ΕR) and progesterone receptors (PR). During proestrus uterine cells showed a weak reaction for both estrogen and progesterone receptors, but during estrus a large number of uterine cells showed a strong reaction on estrogen receptors and moderate reaction on progesterone receptors. On the contrary, during diestrus the scores for the estrogen receptors decreased, while the progesterone receptors level increased - uterine cells expressed strong reaction for progesterone receptors, and moderate reaction for estrogen receptors. Uterine cells in cystic endometrial hyperplasia expressed a strong reaction for estrogen receptors, and moderate reaction for progesterone receptors, but on the other hand the uterine cells in the uterus with pyometra expressed a moderate to strong reaction for progesterone receptors, and a weak reaction for estrogen receptors. In further investigations it would be interesting to perform quantitative analysis for both estrogen and progesterone receptors during different phases of the estrus cycle and also in the uterus with cystic endometrial hyperplasia and pyometra.Marinković DarkoAničić MilanVakanjac SlobodankaNedić SvetlanaMagaš VladimirSciendoarticlebitchesuteruscystic endometrial hyperplasiapyometraestrogen receptorsprogesterone receptorsVeterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 3, Pp 239-250 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	bitches uterus cystic endometrial hyperplasia pyometra estrogen receptors progesterone receptors Veterinary medicine SF600-1100
spellingShingle	bitches uterus cystic endometrial hyperplasia pyometra estrogen receptors progesterone receptors Veterinary medicine SF600-1100 Marinković Darko Aničić Milan Vakanjac Slobodanka Nedić Svetlana Magaš Vladimir Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra
description	The estrus cycle of bitches is divided into four phases: proestrus, estrus, diestrus and anestrus, during which different morphological changes, and also cyclic changes of estrogen and progesterone receptors are present. Several pathological changes can be differentiated on the endometrium, but one of these is the most important - cystic endometrial hyperplasia, which frequently develops into pyometra. The aim of the present study was to describe morphological characteristics, and expression of estrogen and progesterone receptors on the endometrium of mixedbreed bitches during the different phases of the estrus cycle, cystic endometrial hyperplasia and pyometra. The uterus and ovaries of 36 mixed breed bitches in different phases of the estrus cycle and also with cystic endometrial hyperplasia (CEH) and chronic purulent endometritis - pyometra were examined macroscopically, histopathologically, and immunohistochemically for estrogen receptors (ΕR) and progesterone receptors (PR). During proestrus uterine cells showed a weak reaction for both estrogen and progesterone receptors, but during estrus a large number of uterine cells showed a strong reaction on estrogen receptors and moderate reaction on progesterone receptors. On the contrary, during diestrus the scores for the estrogen receptors decreased, while the progesterone receptors level increased - uterine cells expressed strong reaction for progesterone receptors, and moderate reaction for estrogen receptors. Uterine cells in cystic endometrial hyperplasia expressed a strong reaction for estrogen receptors, and moderate reaction for progesterone receptors, but on the other hand the uterine cells in the uterus with pyometra expressed a moderate to strong reaction for progesterone receptors, and a weak reaction for estrogen receptors. In further investigations it would be interesting to perform quantitative analysis for both estrogen and progesterone receptors during different phases of the estrus cycle and also in the uterus with cystic endometrial hyperplasia and pyometra.
format	article
author	Marinković Darko Aničić Milan Vakanjac Slobodanka Nedić Svetlana Magaš Vladimir
author_facet	Marinković Darko Aničić Milan Vakanjac Slobodanka Nedić Svetlana Magaš Vladimir
author_sort	Marinković Darko
title	Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra
title_short	Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra
title_full	Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra
title_fullStr	Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra
title_full_unstemmed	Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra
title_sort	morphological characteristics and expression of estrogen and progesterone receptors in the canine endometrium during the estrus cycle, cystic endometrial hyperplasia and pyometra
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/10216dae8dd1403db6769bc843b516f0
work_keys_str_mv	AT marinkovicdarko morphologicalcharacteristicsandexpressionofestrogenandprogesteronereceptorsinthecanineendometriumduringtheestruscyclecysticendometrialhyperplasiaandpyometra AT anicicmilan morphologicalcharacteristicsandexpressionofestrogenandprogesteronereceptorsinthecanineendometriumduringtheestruscyclecysticendometrialhyperplasiaandpyometra AT vakanjacslobodanka morphologicalcharacteristicsandexpressionofestrogenandprogesteronereceptorsinthecanineendometriumduringtheestruscyclecysticendometrialhyperplasiaandpyometra AT nedicsvetlana morphologicalcharacteristicsandexpressionofestrogenandprogesteronereceptorsinthecanineendometriumduringtheestruscyclecysticendometrialhyperplasiaandpyometra AT magasvladimir morphologicalcharacteristicsandexpressionofestrogenandprogesteronereceptorsinthecanineendometriumduringtheestruscyclecysticendometrialhyperplasiaandpyometra
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Morphological Characteristics and Expression of Estrogen and Progesterone Receptors in the Canine Endometrium During the Estrus Cycle, Cystic Endometrial Hyperplasia and Pyometra

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