Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis

Objective A close relationship of microRNAs (miRNAs) with various human diseases has been widely reported, including cardiovascular disease. The current study attempted to examine the abnormal expression of miR-27b in asymptomatic carotid artery stenosis (ACAS), its diagnostic value and predictive v...

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Autores principales:	Tingting Lu, Xin Li, Chunxi Long, Wenyuan Ji, Linjun Jiang, Jianquan Tian
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/1025292481464b23b900efcf063b9403
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spelling	oai:doaj.org-article:1025292481464b23b900efcf063b94032021-12-02T01:33:32ZCirculating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis1938-272310.1177/10760296211057903https://doaj.org/article/1025292481464b23b900efcf063b94032021-11-01T00:00:00Zhttps://doi.org/10.1177/10760296211057903https://doaj.org/toc/1938-2723Objective A close relationship of microRNAs (miRNAs) with various human diseases has been widely reported, including cardiovascular disease. The current study attempted to examine the abnormal expression of miR-27b in asymptomatic carotid artery stenosis (ACAS), its diagnostic value and predictive value for the development of ACAS were also assessed. Methods Clinical serum samples were collected from both ACAS patients and healthy individuals, and levels of miR-27b in the clinical samples were detected using Real-time quantitative PCR. Cerebral ischemia events (CIEs) of patients during the 5-year follow-up were collected. The diagnostic and predictive values of serum miR-27b was assessed via plotting Receiver operating characteristic (ROC) and Kaplan-Meier curves. Multivariate cox regression analysis was performed for clinical independent index analysis. Results ACAS patients had higher levels of miR-27b than the healthy subjects. There were close association of serum miR-27b levels with total cholesterol (TC) level, absence of hypertension and degree of carotid stenosis. High levels of miR-27b could differentiate ACAS cases from healthy subjects, and predicted the high incidence of CIEs. MiR-27b could be used as an independent predictor of cerebrovascular events via multiple Cox regression analysis ( P = .031). Conclusion The high level of miR-27b can predict the occurrence of ACAS, and is closely related to the subsequent occurrence of CIEs. The present results provide evidence for circulating miR-27b as a diagnostic and prognostic marker in patients with ACAS.Tingting LuXin LiChunxi LongWenyuan JiLinjun JiangJianquan TianSAGE PublishingarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENClinical and Applied Thrombosis/Hemostasis, Vol 27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Tingting Lu Xin Li Chunxi Long Wenyuan Ji Linjun Jiang Jianquan Tian Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis
description	Objective A close relationship of microRNAs (miRNAs) with various human diseases has been widely reported, including cardiovascular disease. The current study attempted to examine the abnormal expression of miR-27b in asymptomatic carotid artery stenosis (ACAS), its diagnostic value and predictive value for the development of ACAS were also assessed. Methods Clinical serum samples were collected from both ACAS patients and healthy individuals, and levels of miR-27b in the clinical samples were detected using Real-time quantitative PCR. Cerebral ischemia events (CIEs) of patients during the 5-year follow-up were collected. The diagnostic and predictive values of serum miR-27b was assessed via plotting Receiver operating characteristic (ROC) and Kaplan-Meier curves. Multivariate cox regression analysis was performed for clinical independent index analysis. Results ACAS patients had higher levels of miR-27b than the healthy subjects. There were close association of serum miR-27b levels with total cholesterol (TC) level, absence of hypertension and degree of carotid stenosis. High levels of miR-27b could differentiate ACAS cases from healthy subjects, and predicted the high incidence of CIEs. MiR-27b could be used as an independent predictor of cerebrovascular events via multiple Cox regression analysis ( P = .031). Conclusion The high level of miR-27b can predict the occurrence of ACAS, and is closely related to the subsequent occurrence of CIEs. The present results provide evidence for circulating miR-27b as a diagnostic and prognostic marker in patients with ACAS.
format	article
author	Tingting Lu Xin Li Chunxi Long Wenyuan Ji Linjun Jiang Jianquan Tian
author_facet	Tingting Lu Xin Li Chunxi Long Wenyuan Ji Linjun Jiang Jianquan Tian
author_sort	Tingting Lu
title	Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis
title_short	Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis
title_full	Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis
title_fullStr	Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis
title_full_unstemmed	Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis
title_sort	circulating mir-27b as a biomarker of the development and progression of carotid artery stenosis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/1025292481464b23b900efcf063b9403
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Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis

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