Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study

Abstract Age-related macular degeneration (AMD) is a degenerative disease of the retina and a leading cause of irreversible vision loss. We investigated the systemic differences in the frequency of T helper (Th) 1 and Th17 cells in patients with non-exudative and exudative AMD and compared to age-ma...

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Autores principales:	Amardeep Singh, Yousif Subhi, Marie Krogh Nielsen, Mads Krüger Falk, Sara Maj Hyldig Matzen, Finn Sellebjerg, Torben Lykke Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/102858b01f364252b9fab59a58af1d40
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spelling	oai:doaj.org-article:102858b01f364252b9fab59a58af1d402021-12-02T15:05:30ZSystemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study10.1038/s41598-017-00741-42045-2322https://doaj.org/article/102858b01f364252b9fab59a58af1d402017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00741-4https://doaj.org/toc/2045-2322Abstract Age-related macular degeneration (AMD) is a degenerative disease of the retina and a leading cause of irreversible vision loss. We investigated the systemic differences in the frequency of T helper (Th) 1 and Th17 cells in patients with non-exudative and exudative AMD and compared to age-matched controls. Flow cytometry was used to determine the systemic frequency of Th1 (CD4+CXCR3+IL12RB2+) and Th17 (CD4+CCR6+IL23R+) cells, and percentage of CD4+ T-cells expressing CXCR3, IL12RB2, CCR6, IL23R, and co-expressing CXCR3 and CCR6. The frequency of Th1 cells and CXCR3+ CD4+ T-cells was lower in patients with exudative AMD. A significant age-dependent decrement in Th1 was observed in controls, but not in non-exudative or exudative AMD. This may be related to the CXCR3+ CD4+ T-cells, which showed similar pattern in controls, but not in non-exudative or exudative AMD. No significant group differences were observed for the frequency of Th17 cells. Correlation networks found several differences between controls and AMD. These data suggests the involvement of the adaptive immune system in AMD and supports the notion of AMD as a systemic disease. Our observations warrant further investigation into the role of the adaptive immune system in the pathogenesis of AMD.Amardeep SinghYousif SubhiMarie Krogh NielsenMads Krüger FalkSara Maj Hyldig MatzenFinn SellebjergTorben Lykke SørensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amardeep Singh Yousif Subhi Marie Krogh Nielsen Mads Krüger Falk Sara Maj Hyldig Matzen Finn Sellebjerg Torben Lykke Sørensen Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study
description	Abstract Age-related macular degeneration (AMD) is a degenerative disease of the retina and a leading cause of irreversible vision loss. We investigated the systemic differences in the frequency of T helper (Th) 1 and Th17 cells in patients with non-exudative and exudative AMD and compared to age-matched controls. Flow cytometry was used to determine the systemic frequency of Th1 (CD4+CXCR3+IL12RB2+) and Th17 (CD4+CCR6+IL23R+) cells, and percentage of CD4+ T-cells expressing CXCR3, IL12RB2, CCR6, IL23R, and co-expressing CXCR3 and CCR6. The frequency of Th1 cells and CXCR3+ CD4+ T-cells was lower in patients with exudative AMD. A significant age-dependent decrement in Th1 was observed in controls, but not in non-exudative or exudative AMD. This may be related to the CXCR3+ CD4+ T-cells, which showed similar pattern in controls, but not in non-exudative or exudative AMD. No significant group differences were observed for the frequency of Th17 cells. Correlation networks found several differences between controls and AMD. These data suggests the involvement of the adaptive immune system in AMD and supports the notion of AMD as a systemic disease. Our observations warrant further investigation into the role of the adaptive immune system in the pathogenesis of AMD.
format	article
author	Amardeep Singh Yousif Subhi Marie Krogh Nielsen Mads Krüger Falk Sara Maj Hyldig Matzen Finn Sellebjerg Torben Lykke Sørensen
author_facet	Amardeep Singh Yousif Subhi Marie Krogh Nielsen Mads Krüger Falk Sara Maj Hyldig Matzen Finn Sellebjerg Torben Lykke Sørensen
author_sort	Amardeep Singh
title	Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study
title_short	Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study
title_full	Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study
title_fullStr	Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study
title_full_unstemmed	Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study
title_sort	systemic frequencies of t helper 1 and t helper 17 cells in patients with age-related macular degeneration: a case-control study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/102858b01f364252b9fab59a58af1d40
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_version_	1718388813014761472

Systemic frequencies of T helper 1 and T helper 17 cells in patients with age-related macular degeneration: A case-control study

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