Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development

Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development

Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation o...

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Autores principales: Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y. Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/102b38001d4a4513871efcad72767745
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spelling oai:doaj.org-article:102b38001d4a4513871efcad727677452021-12-02T15:33:05ZGlucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development10.1038/s41467-021-24619-22041-1723https://doaj.org/article/102b38001d4a4513871efcad727677452021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24619-2https://doaj.org/toc/2041-1723Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to induce mitochondrial fusion.Jianli HeXun ShangguanWei ZhouYing CaoQuan ZhengJun TuGaolei HuZi LiangCen JiangLiufu DengShengdian WangWen YangYong ZuoJiao MaRong CaiYalan ChenQiuju FanBaijun DongWei XueHongsheng TanYitao QiJianmin GuBing SuY. Eugene ChinGuoqiang ChenQi WangTianshi WangJinke ChengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jianli He
Xun Shangguan
Wei Zhou
Ying Cao
Quan Zheng
Jun Tu
Gaolei Hu
Zi Liang
Cen Jiang
Liufu Deng
Shengdian Wang
Wen Yang
Yong Zuo
Jiao Ma
Rong Cai
Yalan Chen
Qiuju Fan
Baijun Dong
Wei Xue
Hongsheng Tan
Yitao Qi
Jianmin Gu
Bing Su
Y. Eugene Chin
Guoqiang Chen
Qi Wang
Tianshi Wang
Jinke Cheng
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
description Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to induce mitochondrial fusion.
format article
author Jianli He
Xun Shangguan
Wei Zhou
Ying Cao
Quan Zheng
Jun Tu
Gaolei Hu
Zi Liang
Cen Jiang
Liufu Deng
Shengdian Wang
Wen Yang
Yong Zuo
Jiao Ma
Rong Cai
Yalan Chen
Qiuju Fan
Baijun Dong
Wei Xue
Hongsheng Tan
Yitao Qi
Jianmin Gu
Bing Su
Y. Eugene Chin
Guoqiang Chen
Qi Wang
Tianshi Wang
Jinke Cheng
author_facet Jianli He
Xun Shangguan
Wei Zhou
Ying Cao
Quan Zheng
Jun Tu
Gaolei Hu
Zi Liang
Cen Jiang
Liufu Deng
Shengdian Wang
Wen Yang
Yong Zuo
Jiao Ma
Rong Cai
Yalan Chen
Qiuju Fan
Baijun Dong
Wei Xue
Hongsheng Tan
Yitao Qi
Jianmin Gu
Bing Su
Y. Eugene Chin
Guoqiang Chen
Qi Wang
Tianshi Wang
Jinke Cheng
author_sort Jianli He
title Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
title_short Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
title_full Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
title_fullStr Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
title_full_unstemmed Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development
title_sort glucose limitation activates ampk coupled senp1-sirt3 signalling in mitochondria for t cell memory development
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/102b38001d4a4513871efcad72767745
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