Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.

Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.

EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing of tyrosinase, a tumour antigen overexpressed in...

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Autores principales: Marioara B Marin, Simona Ghenea, Laurentiu N Spiridon, Gabriela N Chiritoiu, Andrei-Jose Petrescu, Stefana-Maria Petrescu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/102caa9e862244ed938780359f9a13ac
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