Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms

Allylation of nucleophiles with less reactive electrophiles, such as carbonates, usually requires a transition-metal catalyst. Here, the authors show a transition-metal-free allylation strategy with allyl ether electrophiles to form homoallylic amine derivatives in up to 92% yield.

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Autores principales: Guogang Deng, Shengzu Duan, Jing Wang, Zhuo Chen, Tongqi Liu, Wen Chen, Hongbin Zhang, Xiaodong Yang, Patrick J. Walsh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/10315b63c9c84de3a31adc1fe7417465
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Sumario:Allylation of nucleophiles with less reactive electrophiles, such as carbonates, usually requires a transition-metal catalyst. Here, the authors show a transition-metal-free allylation strategy with allyl ether electrophiles to form homoallylic amine derivatives in up to 92% yield.