Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms

Allylation of nucleophiles with less reactive electrophiles, such as carbonates, usually requires a transition-metal catalyst. Here, the authors show a transition-metal-free allylation strategy with allyl ether electrophiles to form homoallylic amine derivatives in up to 92% yield.

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Autores principales:	Guogang Deng, Shengzu Duan, Jing Wang, Zhuo Chen, Tongqi Liu, Wen Chen, Hongbin Zhang, Xiaodong Yang, Patrick J. Walsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10315b63c9c84de3a31adc1fe7417465
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spelling	oai:doaj.org-article:10315b63c9c84de3a31adc1fe74174652021-12-02T17:44:52ZTransition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms10.1038/s41467-021-24027-62041-1723https://doaj.org/article/10315b63c9c84de3a31adc1fe74174652021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24027-6https://doaj.org/toc/2041-1723Allylation of nucleophiles with less reactive electrophiles, such as carbonates, usually requires a transition-metal catalyst. Here, the authors show a transition-metal-free allylation strategy with allyl ether electrophiles to form homoallylic amine derivatives in up to 92% yield.Guogang DengShengzu DuanJing WangZhuo ChenTongqi LiuWen ChenHongbin ZhangXiaodong YangPatrick J. WalshNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guogang Deng Shengzu Duan Jing Wang Zhuo Chen Tongqi Liu Wen Chen Hongbin Zhang Xiaodong Yang Patrick J. Walsh Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
description	Allylation of nucleophiles with less reactive electrophiles, such as carbonates, usually requires a transition-metal catalyst. Here, the authors show a transition-metal-free allylation strategy with allyl ether electrophiles to form homoallylic amine derivatives in up to 92% yield.
format	article
author	Guogang Deng Shengzu Duan Jing Wang Zhuo Chen Tongqi Liu Wen Chen Hongbin Zhang Xiaodong Yang Patrick J. Walsh
author_facet	Guogang Deng Shengzu Duan Jing Wang Zhuo Chen Tongqi Liu Wen Chen Hongbin Zhang Xiaodong Yang Patrick J. Walsh
author_sort	Guogang Deng
title	Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
title_short	Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
title_full	Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
title_fullStr	Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
title_full_unstemmed	Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
title_sort	transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10315b63c9c84de3a31adc1fe7417465
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Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms

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