Cryo-EM structure of type 1 IP3R channel in a lipid bilayer

3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structurally diverse, homo-tetrameric ion channels.

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Autores principales:	Mariah R. Baker, Guizhen Fan, Alexander B. Seryshev, Melina A. Agosto, Matthew L. Baker, Irina I. Serysheva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/10329eb0880f42febb3dead68ecf9485
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spelling	oai:doaj.org-article:10329eb0880f42febb3dead68ecf94852021-12-02T16:53:10ZCryo-EM structure of type 1 IP3R channel in a lipid bilayer10.1038/s42003-021-02156-42399-3642https://doaj.org/article/10329eb0880f42febb3dead68ecf94852021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02156-4https://doaj.org/toc/2399-36423D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structurally diverse, homo-tetrameric ion channels.Mariah R. BakerGuizhen FanAlexander B. SeryshevMelina A. AgostoMatthew L. BakerIrina I. SeryshevaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mariah R. Baker Guizhen Fan Alexander B. Seryshev Melina A. Agosto Matthew L. Baker Irina I. Serysheva Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
description	3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structurally diverse, homo-tetrameric ion channels.
format	article
author	Mariah R. Baker Guizhen Fan Alexander B. Seryshev Melina A. Agosto Matthew L. Baker Irina I. Serysheva
author_facet	Mariah R. Baker Guizhen Fan Alexander B. Seryshev Melina A. Agosto Matthew L. Baker Irina I. Serysheva
author_sort	Mariah R. Baker
title	Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
title_short	Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
title_full	Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
title_fullStr	Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
title_full_unstemmed	Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
title_sort	cryo-em structure of type 1 ip3r channel in a lipid bilayer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10329eb0880f42febb3dead68ecf9485
work_keys_str_mv	AT mariahrbaker cryoemstructureoftype1ip3rchannelinalipidbilayer AT guizhenfan cryoemstructureoftype1ip3rchannelinalipidbilayer AT alexanderbseryshev cryoemstructureoftype1ip3rchannelinalipidbilayer AT melinaaagosto cryoemstructureoftype1ip3rchannelinalipidbilayer AT matthewlbaker cryoemstructureoftype1ip3rchannelinalipidbilayer AT irinaiserysheva cryoemstructureoftype1ip3rchannelinalipidbilayer
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Cryo-EM structure of type 1 IP3R channel in a lipid bilayer

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