Role of the posterior mucosal defense barrier in portal hypertensive gastropathy

Portal hypertensive gastropathy (PHG) is a complication of cirrhotic or noncirrhotic portal hypertension. PHG is very important in the clinic because it can cause acute or even massive blood loss, and its treatment efficacy and prognosis are poor. Currently, the incidence of PHG in patients with cir...

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Autores principales:	Zhiqiang Yi, Minglin Zhang, Zhiyuan Ma, Biguang Tuo, Aimin Liu, Zilin Deng, Yingying Zhao, Taolang Li, Xuemei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Portal hypertensive gastropathy Posterior mucosal defense barrier Microvascular endothelial cells Ischemia-reperfusion injury Endothelial cell dysfunction Endothelial cell molecules Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1033f5060d8b43969c4dd9e8ab44e855
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spelling	oai:doaj.org-article:1033f5060d8b43969c4dd9e8ab44e8552021-11-14T04:28:55ZRole of the posterior mucosal defense barrier in portal hypertensive gastropathy0753-332210.1016/j.biopha.2021.112258https://doaj.org/article/1033f5060d8b43969c4dd9e8ab44e8552021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010428https://doaj.org/toc/0753-3322Portal hypertensive gastropathy (PHG) is a complication of cirrhotic or noncirrhotic portal hypertension. PHG is very important in the clinic because it can cause acute or even massive blood loss, and its treatment efficacy and prognosis are poor. Currently, the incidence of PHG in patients with cirrhosis is 20–80%, but its pathogenesis is complicated and poorly understood. Studies have shown that portal hypertension can cause changes in gastric mucosal microcirculation hemodynamics, leading to changes in gastric mucosal histology and function and thereby weakening the mucosal defense barrier. However, no specific drug treatment plans are currently available. This article reviews the current literature to further our understanding of the mechanism underlying PHG and the relationship between PHG and the posterior mucosal defense barrier and to explore new therapeutic targets.Zhiqiang YiMinglin ZhangZhiyuan MaBiguang TuoAimin LiuZilin DengYingying ZhaoTaolang LiXuemei LiuElsevierarticlePortal hypertensive gastropathyPosterior mucosal defense barrierMicrovascular endothelial cellsIschemia-reperfusion injuryEndothelial cell dysfunctionEndothelial cell moleculesTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112258- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Portal hypertensive gastropathy Posterior mucosal defense barrier Microvascular endothelial cells Ischemia-reperfusion injury Endothelial cell dysfunction Endothelial cell molecules Therapeutics. Pharmacology RM1-950
spellingShingle	Portal hypertensive gastropathy Posterior mucosal defense barrier Microvascular endothelial cells Ischemia-reperfusion injury Endothelial cell dysfunction Endothelial cell molecules Therapeutics. Pharmacology RM1-950 Zhiqiang Yi Minglin Zhang Zhiyuan Ma Biguang Tuo Aimin Liu Zilin Deng Yingying Zhao Taolang Li Xuemei Liu Role of the posterior mucosal defense barrier in portal hypertensive gastropathy
description	Portal hypertensive gastropathy (PHG) is a complication of cirrhotic or noncirrhotic portal hypertension. PHG is very important in the clinic because it can cause acute or even massive blood loss, and its treatment efficacy and prognosis are poor. Currently, the incidence of PHG in patients with cirrhosis is 20–80%, but its pathogenesis is complicated and poorly understood. Studies have shown that portal hypertension can cause changes in gastric mucosal microcirculation hemodynamics, leading to changes in gastric mucosal histology and function and thereby weakening the mucosal defense barrier. However, no specific drug treatment plans are currently available. This article reviews the current literature to further our understanding of the mechanism underlying PHG and the relationship between PHG and the posterior mucosal defense barrier and to explore new therapeutic targets.
format	article
author	Zhiqiang Yi Minglin Zhang Zhiyuan Ma Biguang Tuo Aimin Liu Zilin Deng Yingying Zhao Taolang Li Xuemei Liu
author_facet	Zhiqiang Yi Minglin Zhang Zhiyuan Ma Biguang Tuo Aimin Liu Zilin Deng Yingying Zhao Taolang Li Xuemei Liu
author_sort	Zhiqiang Yi
title	Role of the posterior mucosal defense barrier in portal hypertensive gastropathy
title_short	Role of the posterior mucosal defense barrier in portal hypertensive gastropathy
title_full	Role of the posterior mucosal defense barrier in portal hypertensive gastropathy
title_fullStr	Role of the posterior mucosal defense barrier in portal hypertensive gastropathy
title_full_unstemmed	Role of the posterior mucosal defense barrier in portal hypertensive gastropathy
title_sort	role of the posterior mucosal defense barrier in portal hypertensive gastropathy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1033f5060d8b43969c4dd9e8ab44e855
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Role of the posterior mucosal defense barrier in portal hypertensive gastropathy

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