Epigenetic landscape influences the liver cancer genome architecture

Epigenetic landscape influences the liver cancer genome architecture

Genomic aberrations contribute to the development of cancer; however, their interdependence remains poorly understood. Here the authors analyze liver cancer samples to find correlation between epigenetic features and genetic aberrations including somatic substitutions, mutation signatures, and HBV i...

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Autores principales: Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito, Tatsuhiro Shibata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/103a2a78264e49439ad7afad15a26081
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spelling oai:doaj.org-article:103a2a78264e49439ad7afad15a260812021-12-02T14:39:22ZEpigenetic landscape influences the liver cancer genome architecture10.1038/s41467-018-03999-y2041-1723https://doaj.org/article/103a2a78264e49439ad7afad15a260812018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03999-yhttps://doaj.org/toc/2041-1723Genomic aberrations contribute to the development of cancer; however, their interdependence remains poorly understood. Here the authors analyze liver cancer samples to find correlation between epigenetic features and genetic aberrations including somatic substitutions, mutation signatures, and HBV integration sites.Natsuko HamaYasushi TotokiFumihito MiuraKenji TatsunoMihoko Saito-AdachiHiromi NakamuraYasuhito AraiFumie HosodaTomoko UrushidateShoko OhashiWakako MukaiNobuyoshi HiraokaHiroyuki AburataniTakashi ItoTatsuhiro ShibataNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Natsuko Hama
Yasushi Totoki
Fumihito Miura
Kenji Tatsuno
Mihoko Saito-Adachi
Hiromi Nakamura
Yasuhito Arai
Fumie Hosoda
Tomoko Urushidate
Shoko Ohashi
Wakako Mukai
Nobuyoshi Hiraoka
Hiroyuki Aburatani
Takashi Ito
Tatsuhiro Shibata
Epigenetic landscape influences the liver cancer genome architecture
description Genomic aberrations contribute to the development of cancer; however, their interdependence remains poorly understood. Here the authors analyze liver cancer samples to find correlation between epigenetic features and genetic aberrations including somatic substitutions, mutation signatures, and HBV integration sites.
format article
author Natsuko Hama
Yasushi Totoki
Fumihito Miura
Kenji Tatsuno
Mihoko Saito-Adachi
Hiromi Nakamura
Yasuhito Arai
Fumie Hosoda
Tomoko Urushidate
Shoko Ohashi
Wakako Mukai
Nobuyoshi Hiraoka
Hiroyuki Aburatani
Takashi Ito
Tatsuhiro Shibata
author_facet Natsuko Hama
Yasushi Totoki
Fumihito Miura
Kenji Tatsuno
Mihoko Saito-Adachi
Hiromi Nakamura
Yasuhito Arai
Fumie Hosoda
Tomoko Urushidate
Shoko Ohashi
Wakako Mukai
Nobuyoshi Hiraoka
Hiroyuki Aburatani
Takashi Ito
Tatsuhiro Shibata
author_sort Natsuko Hama
title Epigenetic landscape influences the liver cancer genome architecture
title_short Epigenetic landscape influences the liver cancer genome architecture
title_full Epigenetic landscape influences the liver cancer genome architecture
title_fullStr Epigenetic landscape influences the liver cancer genome architecture
title_full_unstemmed Epigenetic landscape influences the liver cancer genome architecture
title_sort epigenetic landscape influences the liver cancer genome architecture
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/103a2a78264e49439ad7afad15a26081
work_keys_str_mv AT natsukohama epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT yasushitotoki epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT fumihitomiura epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT kenjitatsuno epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT mihokosaitoadachi epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT hirominakamura epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT yasuhitoarai epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT fumiehosoda epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT tomokourushidate epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT shokoohashi epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT wakakomukai epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT nobuyoshihiraoka epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT hiroyukiaburatani epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT takashiito epigeneticlandscapeinfluencesthelivercancergenomearchitecture
AT tatsuhiroshibata epigeneticlandscapeinfluencesthelivercancergenomearchitecture
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