A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation

A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation

Here, the authors combine 16 S rRNA sequencing, culture and bioinformatics to profile the microbiome in 234 serial bronchoalveolar lavage samples from 64 lung transplant recipients collected over 49-months and identify distinct compositional states, termed pneumotypes, linked to current health statu...

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Main Authors: Sudip Das, Eric Bernasconi, Angela Koutsokera, Daniel-Adrien Wurlod, Vishwachi Tripathi, Germán Bonilla-Rosso, John-David Aubert, Marie-France Derkenne, Louis Mercier, Céline Pattaroni, Alexis Rapin, Christophe von Garnier, Benjamin J. Marsland, Philipp Engel, Laurent P. Nicod
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/103af543cb0b4fbe9b0c1efa75e5169d
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Summary:Here, the authors combine 16 S rRNA sequencing, culture and bioinformatics to profile the microbiome in 234 serial bronchoalveolar lavage samples from 64 lung transplant recipients collected over 49-months and identify distinct compositional states, termed pneumotypes, linked to current health status, and establish a collection of primary lung bacterial isolates, LuMiCol.

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