The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species, and rejuvenated aged HSCs.

Guardado en:

Detalles Bibliográficos
Autores principales:	Kentaro Hosokawa, Ben D. MacArthur, Yoshiko Matsumoto Ikushima, Hirofumi Toyama, Yoshikazu Masuhiro, Shigemasa Hanazawa, Toshio Suda, Fumio Arai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/103e2c9006e24accbe1d6a3f00d0aa0c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:103e2c9006e24accbe1d6a3f00d0aa0c
record_format	dspace
spelling	oai:doaj.org-article:103e2c9006e24accbe1d6a3f00d0aa0c2021-12-02T15:38:42ZThe telomere binding protein Pot1 maintains haematopoietic stem cell activity with age10.1038/s41467-017-00935-42041-1723https://doaj.org/article/103e2c9006e24accbe1d6a3f00d0aa0c2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00935-4https://doaj.org/toc/2041-1723Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species, and rejuvenated aged HSCs.Kentaro HosokawaBen D. MacArthurYoshiko Matsumoto IkushimaHirofumi ToyamaYoshikazu MasuhiroShigemasa HanazawaToshio SudaFumio AraiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kentaro Hosokawa Ben D. MacArthur Yoshiko Matsumoto Ikushima Hirofumi Toyama Yoshikazu Masuhiro Shigemasa Hanazawa Toshio Suda Fumio Arai The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
description	Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species, and rejuvenated aged HSCs.
format	article
author	Kentaro Hosokawa Ben D. MacArthur Yoshiko Matsumoto Ikushima Hirofumi Toyama Yoshikazu Masuhiro Shigemasa Hanazawa Toshio Suda Fumio Arai
author_facet	Kentaro Hosokawa Ben D. MacArthur Yoshiko Matsumoto Ikushima Hirofumi Toyama Yoshikazu Masuhiro Shigemasa Hanazawa Toshio Suda Fumio Arai
author_sort	Kentaro Hosokawa
title	The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
title_short	The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
title_full	The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
title_fullStr	The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
title_full_unstemmed	The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
title_sort	telomere binding protein pot1 maintains haematopoietic stem cell activity with age
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/103e2c9006e24accbe1d6a3f00d0aa0c
work_keys_str_mv	AT kentarohosokawa thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT bendmacarthur thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT yoshikomatsumotoikushima thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT hirofumitoyama thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT yoshikazumasuhiro thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT shigemasahanazawa thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT toshiosuda thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT fumioarai thetelomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT kentarohosokawa telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT bendmacarthur telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT yoshikomatsumotoikushima telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT hirofumitoyama telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT yoshikazumasuhiro telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT shigemasahanazawa telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT toshiosuda telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage AT fumioarai telomerebindingproteinpot1maintainshaematopoieticstemcellactivitywithage
_version_	1718386094540587008

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Ejemplares similares