Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

Abstract To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet. Thirty-six weanling rats were fed diets containing 3...

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Autores principales:	Joanna Moro, Catherine Chaumontet, Patrick C. Even, Anne Blais, Julien Piedcoq, Claire Gaudichon, Daniel Tomé, Dalila Azzout-Marniche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/103f23377add46af847c6b25c573a42b
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spelling	oai:doaj.org-article:103f23377add46af847c6b25c573a42b2021-12-02T16:04:27ZSevere protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats10.1038/s41598-021-91274-42045-2322https://doaj.org/article/103f23377add46af847c6b25c573a42b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91274-4https://doaj.org/toc/2045-2322Abstract To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet. Thirty-six weanling rats were fed diets containing 3%, 5%, 8%, 12%, 15% and 20% protein for three weeks. Body weight, food intake, energy expenditure and metabolic parameters were followed throughout this period. The very low-protein diets (3% and 5%) induced a large decrease in body weight gain and an increase in energy intake relative to body mass. No gain in fat mass was observed because energy expenditure increased in proportion to energy intake. As expected, Fgf21 expression in the liver and plasma FGF21 increased with low-protein diets, but Fgf21 expression in the hypothalamus decreased. Under low protein diets (3% and 5%), the increase in liver Fgf21 and the decrease of Fgf21 in the hypothalamus induced an increase in energy expenditure and the decrease in the satiety signal responsible for hyperphagia. Our results highlight that when dietary protein decreases below 8%, the liver detects the low protein diet and responds by activating synthesis and secretion of FGF21 in order to activate an endocrine signal that induces metabolic adaptation. The hypothalamus, in comparison, responds to protein deficiency when dietary protein decreases below 5%.Joanna MoroCatherine ChaumontetPatrick C. EvenAnne BlaisJulien PiedcoqClaire GaudichonDaniel ToméDalila Azzout-MarnicheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Moro Catherine Chaumontet Patrick C. Even Anne Blais Julien Piedcoq Claire Gaudichon Daniel Tomé Dalila Azzout-Marniche Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
description	Abstract To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet. Thirty-six weanling rats were fed diets containing 3%, 5%, 8%, 12%, 15% and 20% protein for three weeks. Body weight, food intake, energy expenditure and metabolic parameters were followed throughout this period. The very low-protein diets (3% and 5%) induced a large decrease in body weight gain and an increase in energy intake relative to body mass. No gain in fat mass was observed because energy expenditure increased in proportion to energy intake. As expected, Fgf21 expression in the liver and plasma FGF21 increased with low-protein diets, but Fgf21 expression in the hypothalamus decreased. Under low protein diets (3% and 5%), the increase in liver Fgf21 and the decrease of Fgf21 in the hypothalamus induced an increase in energy expenditure and the decrease in the satiety signal responsible for hyperphagia. Our results highlight that when dietary protein decreases below 8%, the liver detects the low protein diet and responds by activating synthesis and secretion of FGF21 in order to activate an endocrine signal that induces metabolic adaptation. The hypothalamus, in comparison, responds to protein deficiency when dietary protein decreases below 5%.
format	article
author	Joanna Moro Catherine Chaumontet Patrick C. Even Anne Blais Julien Piedcoq Claire Gaudichon Daniel Tomé Dalila Azzout-Marniche
author_facet	Joanna Moro Catherine Chaumontet Patrick C. Even Anne Blais Julien Piedcoq Claire Gaudichon Daniel Tomé Dalila Azzout-Marniche
author_sort	Joanna Moro
title	Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
title_short	Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
title_full	Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
title_fullStr	Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
title_full_unstemmed	Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
title_sort	severe protein deficiency induces hepatic expression and systemic level of fgf21 but inhibits its hypothalamic expression in growing rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/103f23377add46af847c6b25c573a42b
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Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

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