Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study

Shuang Jiang,1,2 Ke Zheng,3 Wei Wang,3 Yi Pei,3 Enduo Qiu,3 Gang Zhu1,4 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Pain Medicine (Psychology Clinic), Cancer Hospital of China Medical Uni...

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Autores principales:	Jiang S, Zheng K, Wang W, Pei Y, Qiu E, Zhu G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	phantom limb pain phantom sensation amputation level preoperative pain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1040572daa8846c9972f8b4a85341c42
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spelling	oai:doaj.org-article:1040572daa8846c9972f8b4a85341c422021-12-02T15:52:56ZPhantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study1178-2021https://doaj.org/article/1040572daa8846c9972f8b4a85341c422021-05-01T00:00:00Zhttps://www.dovepress.com/phantom-limb-pain-and-sensations-in-chinese-malignant-tumor-amputees-a-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Shuang Jiang,1,2 Ke Zheng,3 Wei Wang,3 Yi Pei,3 Enduo Qiu,3 Gang Zhu1,4 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Pain Medicine (Psychology Clinic), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, People’s Republic of China; 3Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, People’s Republic of China; 4Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of ChinaCorrespondence: Gang Zhu Tel/Fax +86-24-83282184Email gzhu@cmu.edu.cnObjective: Phantom limb pain (PLP) was a common problem in malignant tumor amputees that can cause considerable suffering. The purposes of this study were to determine the incidence and factors associated with the occurrence of post-operation PLP, stump limb pain (SLP), and phantom limb sensations (PLS) in tumor amputees within the first month after surgery. Additionally, differences in phantom phenomena between upper and lower extremities were investigated.Methods: In total, 162 amputees participated in this retrospective study who underwent malignant limb amputation between 2012 and 2019. Clinical characteristics were collected from medical records and reconfirmed by telephone interviews. A numerical rating scale (NRS) was used to quantitate phantom phenomena. We used analysis of variance and non-parametric statistics for categorical variables and ordinal variables separately.Results: In the first month after malignant amputation, the incidence of PLP was 54.3%, that of PLS was 65.4%, and that of SLP was 32.7%. The duration of preoperative pain and amputation level was significantly different for the incidence of acute PLP. Further subgroup analysis of amputation level showed that patients whose amputation level was below the wrist and ankle joints had a significantly reduced incidence of PLP (p< 0.0083 in Bonferroni test). Binary logistics regression analysis determined that amputation level was the primary risk factor for the incidence of PLP. Factors related to the severity of postoperative PLP also included amputation level, preoperative pain, and amputation times. By comparing the differences between upper and lower limbs after amputation, we found that the incidence of PLS was higher after lower limb amputation, but there was no significant difference in the incidence of PLP and SLP. Preoperative experience of chemotherapy was not a risk factor for PLP.Conclusion: Proximal amputation and long-term preoperative pain seemed to count more for PLP incidence. Further research may be required to individually determine factors associated with the occurrence and chronicity of phantom phenomena.Keywords: phantom limb pain, phantom sensation, amputation level, preoperative painJiang SZheng KWang WPei YQiu EZhu GDove Medical Pressarticlephantom limb painphantom sensationamputation levelpreoperative painNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1579-1587 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phantom limb pain phantom sensation amputation level preoperative pain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	phantom limb pain phantom sensation amputation level preoperative pain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jiang S Zheng K Wang W Pei Y Qiu E Zhu G Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study
description	Shuang Jiang,1,2 Ke Zheng,3 Wei Wang,3 Yi Pei,3 Enduo Qiu,3 Gang Zhu1,4 1Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 2Department of Pain Medicine (Psychology Clinic), Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, People’s Republic of China; 3Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, 110042, People’s Republic of China; 4Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of ChinaCorrespondence: Gang Zhu Tel/Fax +86-24-83282184Email gzhu@cmu.edu.cnObjective: Phantom limb pain (PLP) was a common problem in malignant tumor amputees that can cause considerable suffering. The purposes of this study were to determine the incidence and factors associated with the occurrence of post-operation PLP, stump limb pain (SLP), and phantom limb sensations (PLS) in tumor amputees within the first month after surgery. Additionally, differences in phantom phenomena between upper and lower extremities were investigated.Methods: In total, 162 amputees participated in this retrospective study who underwent malignant limb amputation between 2012 and 2019. Clinical characteristics were collected from medical records and reconfirmed by telephone interviews. A numerical rating scale (NRS) was used to quantitate phantom phenomena. We used analysis of variance and non-parametric statistics for categorical variables and ordinal variables separately.Results: In the first month after malignant amputation, the incidence of PLP was 54.3%, that of PLS was 65.4%, and that of SLP was 32.7%. The duration of preoperative pain and amputation level was significantly different for the incidence of acute PLP. Further subgroup analysis of amputation level showed that patients whose amputation level was below the wrist and ankle joints had a significantly reduced incidence of PLP (p< 0.0083 in Bonferroni test). Binary logistics regression analysis determined that amputation level was the primary risk factor for the incidence of PLP. Factors related to the severity of postoperative PLP also included amputation level, preoperative pain, and amputation times. By comparing the differences between upper and lower limbs after amputation, we found that the incidence of PLS was higher after lower limb amputation, but there was no significant difference in the incidence of PLP and SLP. Preoperative experience of chemotherapy was not a risk factor for PLP.Conclusion: Proximal amputation and long-term preoperative pain seemed to count more for PLP incidence. Further research may be required to individually determine factors associated with the occurrence and chronicity of phantom phenomena.Keywords: phantom limb pain, phantom sensation, amputation level, preoperative pain
format	article
author	Jiang S Zheng K Wang W Pei Y Qiu E Zhu G
author_facet	Jiang S Zheng K Wang W Pei Y Qiu E Zhu G
author_sort	Jiang S
title	Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study
title_short	Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study
title_full	Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study
title_fullStr	Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study
title_full_unstemmed	Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study
title_sort	phantom limb pain and sensations in chinese malignant tumor amputees: a retrospective epidemiological study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1040572daa8846c9972f8b4a85341c42
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Phantom Limb Pain and Sensations in Chinese Malignant Tumor Amputees: A Retrospective Epidemiological Study

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