Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides

Protein phosphorylation mediates signalling and other important cellular processes, but the specific effect of cysteine phosphorylation is unclear. Here, the authors present a chemical strategy to selectively phosphorylate cysteine residues and a mass spectrometry approach to detect and characterize...

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Autores principales:	Jordi Bertran-Vicente, Martin Penkert, Olaia Nieto-Garcia, Jean-Marc Jeckelmann, Peter Schmieder, Eberhard Krause, Christian P. R. Hackenberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1040c880158d473390673af6b138aded
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spelling	oai:doaj.org-article:1040c880158d473390673af6b138aded2021-12-02T14:40:13ZChemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides10.1038/ncomms127032041-1723https://doaj.org/article/1040c880158d473390673af6b138aded2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12703https://doaj.org/toc/2041-1723Protein phosphorylation mediates signalling and other important cellular processes, but the specific effect of cysteine phosphorylation is unclear. Here, the authors present a chemical strategy to selectively phosphorylate cysteine residues and a mass spectrometry approach to detect and characterize endogenous pCys sites.Jordi Bertran-VicenteMartin PenkertOlaia Nieto-GarciaJean-Marc JeckelmannPeter SchmiederEberhard KrauseChristian P. R. HackenbergerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordi Bertran-Vicente Martin Penkert Olaia Nieto-Garcia Jean-Marc Jeckelmann Peter Schmieder Eberhard Krause Christian P. R. Hackenberger Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
description	Protein phosphorylation mediates signalling and other important cellular processes, but the specific effect of cysteine phosphorylation is unclear. Here, the authors present a chemical strategy to selectively phosphorylate cysteine residues and a mass spectrometry approach to detect and characterize endogenous pCys sites.
format	article
author	Jordi Bertran-Vicente Martin Penkert Olaia Nieto-Garcia Jean-Marc Jeckelmann Peter Schmieder Eberhard Krause Christian P. R. Hackenberger
author_facet	Jordi Bertran-Vicente Martin Penkert Olaia Nieto-Garcia Jean-Marc Jeckelmann Peter Schmieder Eberhard Krause Christian P. R. Hackenberger
author_sort	Jordi Bertran-Vicente
title	Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
title_short	Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
title_full	Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
title_fullStr	Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
title_full_unstemmed	Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
title_sort	chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1040c880158d473390673af6b138aded
work_keys_str_mv	AT jordibertranvicente chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides AT martinpenkert chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides AT olaianietogarcia chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides AT jeanmarcjeckelmann chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides AT peterschmieder chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides AT eberhardkrause chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides AT christianprhackenberger chemoselectivesynthesisandanalysisofnaturallyoccurringphosphorylatedcysteinepeptides
_version_	1718390338328985600

Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides

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