A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations
Abstract Analysing pig class II mayor histocompatibility complex (MHC) molecules is mainly related to antigen presentation. Identifying frequently-occurring alleles in pig populations is an important aspect to be considered when developing peptide-based vaccines. Colombian creole pig populations hav...
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Nature Portfolio
2021
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oai:doaj.org-article:1043fc0567c441759ea818f79f8d1e2e2021-12-02T16:23:21ZA comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations10.1038/s41598-021-83637-82045-2322https://doaj.org/article/1043fc0567c441759ea818f79f8d1e2e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83637-8https://doaj.org/toc/2045-2322Abstract Analysing pig class II mayor histocompatibility complex (MHC) molecules is mainly related to antigen presentation. Identifying frequently-occurring alleles in pig populations is an important aspect to be considered when developing peptide-based vaccines. Colombian creole pig populations have had to adapt to local conditions since entering Colombia; a recent census has shown low amounts of pigs which is why they are considered protected by the Colombian government. Commercial hybrids are more attractive regarding production. This research has been aimed at describing the allele distribution of Colombian pigs from diverse genetic backgrounds and comparing Colombian SLA-DRB1 locus diversity to that of internationally reported populations. Twenty SLA-DRB1 alleles were identified in the six populations analysed here using sequence-based typing. The amount of alleles ranged from six (Manta and Casco Mula) to nine (San Pedreño). Only one allele (01:02) having > 5% frequency was shared by all three commercial line populations. Allele 02:01:01 was shared by five populations (around > 5% frequency). Global FST indicated that pig populations were clearly structured, as 20.6% of total allele frequency variation was explained by differences between populations (F ST = 0.206). This study’s results confirmed that the greatest diversity occurred in wild boars, thereby contrasting with low diversity in domestic pig populations.Carmen Teresa Celis-GiraldoMichel David BohórquezMilena CamargoCarlos Fernando SuárezAnny CamargoKewin Rodríguez-ObedienteAlejandra MartínezCarlos Edmundo LuceroByron HernándezRaúl Manzano-RománManuel Alfonso PatarroyoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Carmen Teresa Celis-Giraldo Michel David Bohórquez Milena Camargo Carlos Fernando Suárez Anny Camargo Kewin Rodríguez-Obediente Alejandra Martínez Carlos Edmundo Lucero Byron Hernández Raúl Manzano-Román Manuel Alfonso Patarroyo A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations |
| description |
Abstract Analysing pig class II mayor histocompatibility complex (MHC) molecules is mainly related to antigen presentation. Identifying frequently-occurring alleles in pig populations is an important aspect to be considered when developing peptide-based vaccines. Colombian creole pig populations have had to adapt to local conditions since entering Colombia; a recent census has shown low amounts of pigs which is why they are considered protected by the Colombian government. Commercial hybrids are more attractive regarding production. This research has been aimed at describing the allele distribution of Colombian pigs from diverse genetic backgrounds and comparing Colombian SLA-DRB1 locus diversity to that of internationally reported populations. Twenty SLA-DRB1 alleles were identified in the six populations analysed here using sequence-based typing. The amount of alleles ranged from six (Manta and Casco Mula) to nine (San Pedreño). Only one allele (01:02) having > 5% frequency was shared by all three commercial line populations. Allele 02:01:01 was shared by five populations (around > 5% frequency). Global FST indicated that pig populations were clearly structured, as 20.6% of total allele frequency variation was explained by differences between populations (F ST = 0.206). This study’s results confirmed that the greatest diversity occurred in wild boars, thereby contrasting with low diversity in domestic pig populations. |
| format |
article |
| author |
Carmen Teresa Celis-Giraldo Michel David Bohórquez Milena Camargo Carlos Fernando Suárez Anny Camargo Kewin Rodríguez-Obediente Alejandra Martínez Carlos Edmundo Lucero Byron Hernández Raúl Manzano-Román Manuel Alfonso Patarroyo |
| author_facet |
Carmen Teresa Celis-Giraldo Michel David Bohórquez Milena Camargo Carlos Fernando Suárez Anny Camargo Kewin Rodríguez-Obediente Alejandra Martínez Carlos Edmundo Lucero Byron Hernández Raúl Manzano-Román Manuel Alfonso Patarroyo |
| author_sort |
Carmen Teresa Celis-Giraldo |
| title |
A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations |
| title_short |
A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations |
| title_full |
A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations |
| title_fullStr |
A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations |
| title_full_unstemmed |
A comparative analysis of SLA-DRB1 genetic diversity in Colombian (creoles and commercial line) and worldwide swine populations |
| title_sort |
comparative analysis of sla-drb1 genetic diversity in colombian (creoles and commercial line) and worldwide swine populations |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1043fc0567c441759ea818f79f8d1e2e |
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