Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6

The origin recognition complex (ORC) is essential for loading the Mcm2–7 replicative helicase onto DNA during DNA replication initiation. Here, the authors describe several cryo-electron microscopy structures of Drosophila ORC bound to DNA and its cofactor Cdc6 and also report an in vitro reconstitu...

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Autores principales: Jan Marten Schmidt, Franziska Bleichert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/104772f99fe64bef9c4c622c3fb6069d
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