Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index

Abstract Association between body mass index (BMI) and coronary heart disease (CHD) in cancer survivors is not clearly established. This study analyzed the prediagnosis BMI-CHD association by examining 13,500 cancer survivors identified from the National Health Insurance Service-Health Screening Coh...

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Autores principales:	Ahryoung Ko, Kyuwoong Kim, Joung Sik Son, Yu Jin Cho, Sang Min Park, Minseon Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10480950907940a28ccb8458dee5613b
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spelling	oai:doaj.org-article:10480950907940a28ccb8458dee5613b2021-12-02T14:16:42ZRisk of coronary heart disease among cancer survivors with different prediagnosis body mass index10.1038/s41598-021-82026-52045-2322https://doaj.org/article/10480950907940a28ccb8458dee5613b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82026-5https://doaj.org/toc/2045-2322Abstract Association between body mass index (BMI) and coronary heart disease (CHD) in cancer survivors is not clearly established. This study analyzed the prediagnosis BMI-CHD association by examining 13,500 cancer survivors identified from the National Health Insurance Service-Health Screening Cohort from January 1, 2004 to December 31, 2009 including the patients who were free of cardiovascular disease at enrollment. The Cox proportional hazards model (adjusted for socioeconomic, health behavior, health status, and medical characteristics) was used for calculating hazard ratios (HR) and 95% confidence intervals (95% CI) for CHD in each prediagnosis BMI category among cancer survivors. Compared to cancer survivors with a prediagnosis BMI between 18.5 and 22.9 kg/m2, those with a prediagnosis BMI of 23.0–24.9 kg/m2 and ≥ 25.0 kg/m2 had significantly higher CHD risk (HR = 1.51; 95% CI: 1.13–2.01 and HR = 1.38; 95% CI: 1.04–1.84, respectively). Cancer survivors with a low prediagnosis BMI (< 18.5 kg/m2) also had significantly higher CHD risk (HR = 1.97; 95% CI: 1.20–3.24) compared to those with a BMI of 18.5–22.9 kg/m2. Similar associations were found after stratifying analyses based on first cancer site and sociodemographic and medical characteristic subgroups. Our study suggests that prediagnosis underweight among patients with cancer is a predictor of CHD risk.Ahryoung KoKyuwoong KimJoung Sik SonYu Jin ChoSang Min ParkMinseon ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ahryoung Ko Kyuwoong Kim Joung Sik Son Yu Jin Cho Sang Min Park Minseon Park Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
description	Abstract Association between body mass index (BMI) and coronary heart disease (CHD) in cancer survivors is not clearly established. This study analyzed the prediagnosis BMI-CHD association by examining 13,500 cancer survivors identified from the National Health Insurance Service-Health Screening Cohort from January 1, 2004 to December 31, 2009 including the patients who were free of cardiovascular disease at enrollment. The Cox proportional hazards model (adjusted for socioeconomic, health behavior, health status, and medical characteristics) was used for calculating hazard ratios (HR) and 95% confidence intervals (95% CI) for CHD in each prediagnosis BMI category among cancer survivors. Compared to cancer survivors with a prediagnosis BMI between 18.5 and 22.9 kg/m2, those with a prediagnosis BMI of 23.0–24.9 kg/m2 and ≥ 25.0 kg/m2 had significantly higher CHD risk (HR = 1.51; 95% CI: 1.13–2.01 and HR = 1.38; 95% CI: 1.04–1.84, respectively). Cancer survivors with a low prediagnosis BMI (< 18.5 kg/m2) also had significantly higher CHD risk (HR = 1.97; 95% CI: 1.20–3.24) compared to those with a BMI of 18.5–22.9 kg/m2. Similar associations were found after stratifying analyses based on first cancer site and sociodemographic and medical characteristic subgroups. Our study suggests that prediagnosis underweight among patients with cancer is a predictor of CHD risk.
format	article
author	Ahryoung Ko Kyuwoong Kim Joung Sik Son Yu Jin Cho Sang Min Park Minseon Park
author_facet	Ahryoung Ko Kyuwoong Kim Joung Sik Son Yu Jin Cho Sang Min Park Minseon Park
author_sort	Ahryoung Ko
title	Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
title_short	Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
title_full	Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
title_fullStr	Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
title_full_unstemmed	Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
title_sort	risk of coronary heart disease among cancer survivors with different prediagnosis body mass index
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10480950907940a28ccb8458dee5613b
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Risk of coronary heart disease among cancer survivors with different prediagnosis body mass index

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