IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sust...

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Autores principales:	Sissy E. Wamaitha, Katarzyna J. Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy, Shantha K. Mahadevaiah, Lyn Healy, Rebecca A. Lea, Miriam Molina-Arcas, Liani G. Devito, Kay Elder, Phil Snell, Leila Christie, Julian Downward, James M. A. Turner, Kathy K. Niakan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/104a33cb9a9247e1b51c23eb671ab8a2
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id	oai:doaj.org-article:104a33cb9a9247e1b51c23eb671ab8a2
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spelling	oai:doaj.org-article:104a33cb9a9247e1b51c23eb671ab8a22021-12-02T15:39:21ZIGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche10.1038/s41467-020-14629-x2041-1723https://doaj.org/article/104a33cb9a9247e1b51c23eb671ab8a22020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14629-xhttps://doaj.org/toc/2041-1723The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sustain hESCs in the absence of FGF.Sissy E. WamaithaKatarzyna J. GrybelGregorio Alanis-LobatoClaudia GerriSugako OgushiAfshan McCarthyShantha K. MahadevaiahLyn HealyRebecca A. LeaMiriam Molina-ArcasLiani G. DevitoKay ElderPhil SnellLeila ChristieJulian DownwardJames M. A. TurnerKathy K. NiakanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sissy E. Wamaitha Katarzyna J. Grybel Gregorio Alanis-Lobato Claudia Gerri Sugako Ogushi Afshan McCarthy Shantha K. Mahadevaiah Lyn Healy Rebecca A. Lea Miriam Molina-Arcas Liani G. Devito Kay Elder Phil Snell Leila Christie Julian Downward James M. A. Turner Kathy K. Niakan IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
description	The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sustain hESCs in the absence of FGF.
format	article
author	Sissy E. Wamaitha Katarzyna J. Grybel Gregorio Alanis-Lobato Claudia Gerri Sugako Ogushi Afshan McCarthy Shantha K. Mahadevaiah Lyn Healy Rebecca A. Lea Miriam Molina-Arcas Liani G. Devito Kay Elder Phil Snell Leila Christie Julian Downward James M. A. Turner Kathy K. Niakan
author_facet	Sissy E. Wamaitha Katarzyna J. Grybel Gregorio Alanis-Lobato Claudia Gerri Sugako Ogushi Afshan McCarthy Shantha K. Mahadevaiah Lyn Healy Rebecca A. Lea Miriam Molina-Arcas Liani G. Devito Kay Elder Phil Snell Leila Christie Julian Downward James M. A. Turner Kathy K. Niakan
author_sort	Sissy E. Wamaitha
title	IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
title_short	IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
title_full	IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
title_fullStr	IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
title_full_unstemmed	IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
title_sort	igf1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/104a33cb9a9247e1b51c23eb671ab8a2
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IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

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