Spatial distributions of red blood cells significantly alter local haemodynamics.

Although bulk changes in red blood cell concentration between vessels have been well characterised, local distributions are generally overlooked. Red blood cells aggregate, deform and migrate within vessels, forming heterogeneous distributions which have considerable effect on local haemodynamics. T...

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Autores principales:	Joseph M Sherwood, David Holmes, Efstathios Kaliviotis, Stavroula Balabani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1050b04b71344dd7bdc5601c90724beb
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spelling	oai:doaj.org-article:1050b04b71344dd7bdc5601c90724beb2021-11-18T08:14:53ZSpatial distributions of red blood cells significantly alter local haemodynamics.1932-620310.1371/journal.pone.0100473https://doaj.org/article/1050b04b71344dd7bdc5601c90724beb2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24950214/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Although bulk changes in red blood cell concentration between vessels have been well characterised, local distributions are generally overlooked. Red blood cells aggregate, deform and migrate within vessels, forming heterogeneous distributions which have considerable effect on local haemodynamics. The present study reports data on the local distribution of human red blood cells in a sequentially bifurcating microchannel, representing the branching geometry of the microvasculature. Imaging methodologies with simple extrapolations are used to infer three dimensional, time-averaged velocity and haematocrit distributions under a range of flow conditions. Strong correlation between the bluntness of the velocity and haematocrit profiles in the parent branch of the geometry is observed and red blood cell aggregation has a notable effect on the observed trends. The two branches of the first bifurcation show similar characteristics in terms of the shapes of the profiles and the extent of plasma skimming, despite the difference in geometric configuration. In the second bifurcation, considerable asymmetry between the branches in the plasma skimming relationship is observed, and elucidated by considering individual haematocrit profiles. The results of the study highlight the importance of considering local haematocrit distributions in the analysis of blood flow and could lead to more accurate computational models of blood flow in microvascular networks. The experimental approaches developed in this work provide a foundation for further examining the characteristics of microhaemodynamics.Joseph M SherwoodDavid HolmesEfstathios KaliviotisStavroula BalabaniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e100473 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph M Sherwood David Holmes Efstathios Kaliviotis Stavroula Balabani Spatial distributions of red blood cells significantly alter local haemodynamics.
description	Although bulk changes in red blood cell concentration between vessels have been well characterised, local distributions are generally overlooked. Red blood cells aggregate, deform and migrate within vessels, forming heterogeneous distributions which have considerable effect on local haemodynamics. The present study reports data on the local distribution of human red blood cells in a sequentially bifurcating microchannel, representing the branching geometry of the microvasculature. Imaging methodologies with simple extrapolations are used to infer three dimensional, time-averaged velocity and haematocrit distributions under a range of flow conditions. Strong correlation between the bluntness of the velocity and haematocrit profiles in the parent branch of the geometry is observed and red blood cell aggregation has a notable effect on the observed trends. The two branches of the first bifurcation show similar characteristics in terms of the shapes of the profiles and the extent of plasma skimming, despite the difference in geometric configuration. In the second bifurcation, considerable asymmetry between the branches in the plasma skimming relationship is observed, and elucidated by considering individual haematocrit profiles. The results of the study highlight the importance of considering local haematocrit distributions in the analysis of blood flow and could lead to more accurate computational models of blood flow in microvascular networks. The experimental approaches developed in this work provide a foundation for further examining the characteristics of microhaemodynamics.
format	article
author	Joseph M Sherwood David Holmes Efstathios Kaliviotis Stavroula Balabani
author_facet	Joseph M Sherwood David Holmes Efstathios Kaliviotis Stavroula Balabani
author_sort	Joseph M Sherwood
title	Spatial distributions of red blood cells significantly alter local haemodynamics.
title_short	Spatial distributions of red blood cells significantly alter local haemodynamics.
title_full	Spatial distributions of red blood cells significantly alter local haemodynamics.
title_fullStr	Spatial distributions of red blood cells significantly alter local haemodynamics.
title_full_unstemmed	Spatial distributions of red blood cells significantly alter local haemodynamics.
title_sort	spatial distributions of red blood cells significantly alter local haemodynamics.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1050b04b71344dd7bdc5601c90724beb
work_keys_str_mv	AT josephmsherwood spatialdistributionsofredbloodcellssignificantlyalterlocalhaemodynamics AT davidholmes spatialdistributionsofredbloodcellssignificantlyalterlocalhaemodynamics AT efstathioskaliviotis spatialdistributionsofredbloodcellssignificantlyalterlocalhaemodynamics AT stavroulabalabani spatialdistributionsofredbloodcellssignificantlyalterlocalhaemodynamics
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Spatial distributions of red blood cells significantly alter local haemodynamics.

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