Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy

Richa Baronia,1 Manjri Singh,1 Rajat B Gupta,1 Stalin Karuppiah,1 Rajiv Kumar,2 Jodi Belz,2 Rishi Shanker,3 Srinivas Sridhar,2 Surinder P Singh1 1CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, M...

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Autores principales:	Baronia R, Singh M, Gupta RB, Karuppiah S, Kumar R, Belz J, Shanker R, Sridhar S, Singh SP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gold Nanoclusters (GNCs) Radiation Therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1053308b1bbb4ce8bc073d044b9183ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:1053308b1bbb4ce8bc073d044b9183ed2021-12-02T00:48:21ZSynthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy1178-2013https://doaj.org/article/1053308b1bbb4ce8bc073d044b9183ed2018-03-01T00:00:00Zhttps://www.dovepress.com/synthesis-and-characterization-of-multifunctional-gold-nanoclusters-fo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Richa Baronia,1 Manjri Singh,1 Rajat B Gupta,1 Stalin Karuppiah,1 Rajiv Kumar,2 Jodi Belz,2 Rishi Shanker,3 Srinivas Sridhar,2 Surinder P Singh1 1CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, India Abstract: Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines. Keywords: gold nanoclusters, radiation therapyBaronia RSingh MGupta RBKaruppiah SKumar RBelz JShanker RSridhar SSingh SPDove Medical PressarticleGold Nanoclusters (GNCs)Radiation TherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 113-115 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold Nanoclusters (GNCs) Radiation Therapy Medicine (General) R5-920
spellingShingle	Gold Nanoclusters (GNCs) Radiation Therapy Medicine (General) R5-920 Baronia R Singh M Gupta RB Karuppiah S Kumar R Belz J Shanker R Sridhar S Singh SP Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
description	Richa Baronia,1 Manjri Singh,1 Rajat B Gupta,1 Stalin Karuppiah,1 Rajiv Kumar,2 Jodi Belz,2 Rishi Shanker,3 Srinivas Sridhar,2 Surinder P Singh1 1CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, India Abstract: Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines. Keywords: gold nanoclusters, radiation therapy
format	article
author	Baronia R Singh M Gupta RB Karuppiah S Kumar R Belz J Shanker R Sridhar S Singh SP
author_facet	Baronia R Singh M Gupta RB Karuppiah S Kumar R Belz J Shanker R Sridhar S Singh SP
author_sort	Baronia R
title	Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_short	Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_full	Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_fullStr	Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_full_unstemmed	Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_sort	synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1053308b1bbb4ce8bc073d044b9183ed
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Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy

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