Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.
<h4>Background</h4>The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and path...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2010
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| Accès en ligne: | https://doaj.org/article/1053ce57cef44fceb9562c4a059e980a |
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