Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.

Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein.

<h4>Background</h4>The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and path...

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Autores principales: Victoria A Lawson, Brooke Lumicisi, Jeremy Welton, Dorothy Machalek, Katrina Gouramanis, Helen M Klemm, James D Stewart, Colin L Masters, David E Hoke, Steven J Collins, Andrew F Hill
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/1053ce57cef44fceb9562c4a059e980a
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