Compound ex vivo and in silico method for hemodynamic analysis of stented arteries.
Hemodynamic factors such as low wall shear stress have been shown to influence endothelial healing and atherogenesis in stent-free vessels. However, in stented vessels, a reliable quantitative analysis of such relations has not been possible due to the lack of a suitable method for the accurate acqu...
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2013
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oai:doaj.org-article:1054b81c3f7f40a4a81a64e1cab5af042021-11-18T07:53:41ZCompound ex vivo and in silico method for hemodynamic analysis of stented arteries.1932-620310.1371/journal.pone.0058147https://doaj.org/article/1054b81c3f7f40a4a81a64e1cab5af042013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23516442/?tool=EBIhttps://doaj.org/toc/1932-6203Hemodynamic factors such as low wall shear stress have been shown to influence endothelial healing and atherogenesis in stent-free vessels. However, in stented vessels, a reliable quantitative analysis of such relations has not been possible due to the lack of a suitable method for the accurate acquisition of blood flow. The objective of this work was to develop a method for the precise reconstruction of hemodynamics and quantification of wall shear stress in stented vessels. We have developed such a method that can be applied to vessels stented in or ex vivo and processed ex vivo. Here we stented the coronary arteries of ex vivo porcine hearts, performed vascular corrosion casting, acquired the vessel geometry using micro-computed tomography and reconstructed blood flow and shear stress using computational fluid dynamics. The method yields accurate local flow information through anatomic fidelity, capturing in detail the stent geometry, arterial tissue prolapse, radial and axial arterial deformation as well as strut malapposition. This novel compound method may serve as a unique tool for spatially resolved analysis of the relationship between hemodynamic factors and vascular biology. It can further be employed to optimize stent design and stenting strategies.Farhad RikhtegarFernando PachecoChristophe WyssKathryn S StokHeng GeRyan J ChooAldo FerrariDimos PoulikakosRalph MüllerVartan KurtcuogluPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58147 (2013) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Farhad Rikhtegar Fernando Pacheco Christophe Wyss Kathryn S Stok Heng Ge Ryan J Choo Aldo Ferrari Dimos Poulikakos Ralph Müller Vartan Kurtcuoglu Compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| description |
Hemodynamic factors such as low wall shear stress have been shown to influence endothelial healing and atherogenesis in stent-free vessels. However, in stented vessels, a reliable quantitative analysis of such relations has not been possible due to the lack of a suitable method for the accurate acquisition of blood flow. The objective of this work was to develop a method for the precise reconstruction of hemodynamics and quantification of wall shear stress in stented vessels. We have developed such a method that can be applied to vessels stented in or ex vivo and processed ex vivo. Here we stented the coronary arteries of ex vivo porcine hearts, performed vascular corrosion casting, acquired the vessel geometry using micro-computed tomography and reconstructed blood flow and shear stress using computational fluid dynamics. The method yields accurate local flow information through anatomic fidelity, capturing in detail the stent geometry, arterial tissue prolapse, radial and axial arterial deformation as well as strut malapposition. This novel compound method may serve as a unique tool for spatially resolved analysis of the relationship between hemodynamic factors and vascular biology. It can further be employed to optimize stent design and stenting strategies. |
| format |
article |
| author |
Farhad Rikhtegar Fernando Pacheco Christophe Wyss Kathryn S Stok Heng Ge Ryan J Choo Aldo Ferrari Dimos Poulikakos Ralph Müller Vartan Kurtcuoglu |
| author_facet |
Farhad Rikhtegar Fernando Pacheco Christophe Wyss Kathryn S Stok Heng Ge Ryan J Choo Aldo Ferrari Dimos Poulikakos Ralph Müller Vartan Kurtcuoglu |
| author_sort |
Farhad Rikhtegar |
| title |
Compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| title_short |
Compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| title_full |
Compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| title_fullStr |
Compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| title_full_unstemmed |
Compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| title_sort |
compound ex vivo and in silico method for hemodynamic analysis of stented arteries. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/1054b81c3f7f40a4a81a64e1cab5af04 |
| work_keys_str_mv |
AT farhadrikhtegar compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT fernandopacheco compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT christophewyss compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT kathrynsstok compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT hengge compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT ryanjchoo compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT aldoferrari compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT dimospoulikakos compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT ralphmuller compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries AT vartankurtcuoglu compoundexvivoandinsilicomethodforhemodynamicanalysisofstentedarteries |
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1718422772360675328 |