Roles of bile acids in enteric virus replication

Abstract Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients. In the intestines, where enteric viruses replicate, BAs also act as signaling molecules that modulate various biological functions via ac...

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Autores principales:	Fanzhi Kong, Linda J. Saif, Qiuhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bile acids Coronavirus Calicivirus Rotavirus Norovirus Sapovirus Veterinary medicine SF600-1100 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/1055de0ef5d340b99941a73f0f68cc94
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spelling	oai:doaj.org-article:1055de0ef5d340b99941a73f0f68cc942021-11-14T12:06:03ZRoles of bile acids in enteric virus replication10.1186/s44149-021-00003-x2731-0442https://doaj.org/article/1055de0ef5d340b99941a73f0f68cc942021-04-01T00:00:00Zhttps://doi.org/10.1186/s44149-021-00003-xhttps://doaj.org/toc/2731-0442Abstract Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients. In the intestines, where enteric viruses replicate, BAs also act as signaling molecules that modulate various biological functions via activation of specific receptors and cell signaling pathways. To date, BAs present either pro-viral or anti-viral effects for the replication of enteric viruses in vivo and in vitro. In this review, we summarized current information on biosynthesis, transportation and metabolism of BAs and the role of BAs in replication of enteric caliciviruses, rotaviruses, and coronaviruses. We also discussed the application of BAs for cell culture adaptation of fastidious enteric caliciviruses and control of virus infection, which may provide novel insights into the development of antivirals and/or disinfectants for enteric viruses.Fanzhi KongLinda J. SaifQiuhong WangBMCarticleBile acidsCoronavirusCalicivirusRotavirusNorovirusSapovirusVeterinary medicineSF600-1100Public aspects of medicineRA1-1270ENAnimal Diseases, Vol 1, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bile acids Coronavirus Calicivirus Rotavirus Norovirus Sapovirus Veterinary medicine SF600-1100 Public aspects of medicine RA1-1270
spellingShingle	Bile acids Coronavirus Calicivirus Rotavirus Norovirus Sapovirus Veterinary medicine SF600-1100 Public aspects of medicine RA1-1270 Fanzhi Kong Linda J. Saif Qiuhong Wang Roles of bile acids in enteric virus replication
description	Abstract Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients. In the intestines, where enteric viruses replicate, BAs also act as signaling molecules that modulate various biological functions via activation of specific receptors and cell signaling pathways. To date, BAs present either pro-viral or anti-viral effects for the replication of enteric viruses in vivo and in vitro. In this review, we summarized current information on biosynthesis, transportation and metabolism of BAs and the role of BAs in replication of enteric caliciviruses, rotaviruses, and coronaviruses. We also discussed the application of BAs for cell culture adaptation of fastidious enteric caliciviruses and control of virus infection, which may provide novel insights into the development of antivirals and/or disinfectants for enteric viruses.
format	article
author	Fanzhi Kong Linda J. Saif Qiuhong Wang
author_facet	Fanzhi Kong Linda J. Saif Qiuhong Wang
author_sort	Fanzhi Kong
title	Roles of bile acids in enteric virus replication
title_short	Roles of bile acids in enteric virus replication
title_full	Roles of bile acids in enteric virus replication
title_fullStr	Roles of bile acids in enteric virus replication
title_full_unstemmed	Roles of bile acids in enteric virus replication
title_sort	roles of bile acids in enteric virus replication
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1055de0ef5d340b99941a73f0f68cc94
work_keys_str_mv	AT fanzhikong rolesofbileacidsinentericvirusreplication AT lindajsaif rolesofbileacidsinentericvirusreplication AT qiuhongwang rolesofbileacidsinentericvirusreplication
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Roles of bile acids in enteric virus replication

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