The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database

Abstract Existing data on the prognosis and clinicopathological features of patients with metastatic renal cell carcinoma (mRCC) are limited. This study aims to investigate the prognostic value and clinicopathological features of different metastatic sites in patients with mRCC. A dataset from the N...

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Autores principales:	Haibin Wei, Jia Miao, Jianxin Cui, Wei Zheng, Xinpeng Chen, Qi Zhang, Feng Liu, Zujie Mao, Songlin Qiu, Dahong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/105609fee2274917b962f09aa3a2cae0
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spelling	oai:doaj.org-article:105609fee2274917b962f09aa3a2cae02021-12-02T17:19:17ZThe prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database10.1038/s41598-021-97365-62045-2322https://doaj.org/article/105609fee2274917b962f09aa3a2cae02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97365-6https://doaj.org/toc/2045-2322Abstract Existing data on the prognosis and clinicopathological features of patients with metastatic renal cell carcinoma (mRCC) are limited. This study aims to investigate the prognostic value and clinicopathological features of different metastatic sites in patients with mRCC. A dataset from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database consisting of 18 registries (1973–2015) was selected for a retrospective mRCC cohort study. Information was included on the metastatic sites in lung, bone, liver, and brain. Kaplan–Meier analysis was applied to compare the survival distribution. Univariate and multivariate Cox regression models were used to analyze survival outcomes. From the SEER database, a total of 10,410 patients with primary mRCC from 2010 to 2015 were enrolled in this cohort study. Analysis indicated that 54.9%, 37.7%, 19.5%, and 10.4% of patients were found to have lung, bone, liver, and brain metastasis, respectively. There was a significantly higher risk for sarcomatoid RCC patients to develop liver metastasis as compared to patients with clear cell RCC. The median survival for patients with lung, bone, liver, or brain metastasis was 7 months, 7 months, 4 months, and 5 months, respectively. Various clinicopathological features and prognostic values are associated with different metastatic sites. Understanding these differences may enable targeted pre-treatment assessment of primary mRCC and personalized curative intervention for patients.Haibin WeiJia MiaoJianxin CuiWei ZhengXinpeng ChenQi ZhangFeng LiuZujie MaoSonglin QiuDahong ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haibin Wei Jia Miao Jianxin Cui Wei Zheng Xinpeng Chen Qi Zhang Feng Liu Zujie Mao Songlin Qiu Dahong Zhang The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
description	Abstract Existing data on the prognosis and clinicopathological features of patients with metastatic renal cell carcinoma (mRCC) are limited. This study aims to investigate the prognostic value and clinicopathological features of different metastatic sites in patients with mRCC. A dataset from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database consisting of 18 registries (1973–2015) was selected for a retrospective mRCC cohort study. Information was included on the metastatic sites in lung, bone, liver, and brain. Kaplan–Meier analysis was applied to compare the survival distribution. Univariate and multivariate Cox regression models were used to analyze survival outcomes. From the SEER database, a total of 10,410 patients with primary mRCC from 2010 to 2015 were enrolled in this cohort study. Analysis indicated that 54.9%, 37.7%, 19.5%, and 10.4% of patients were found to have lung, bone, liver, and brain metastasis, respectively. There was a significantly higher risk for sarcomatoid RCC patients to develop liver metastasis as compared to patients with clear cell RCC. The median survival for patients with lung, bone, liver, or brain metastasis was 7 months, 7 months, 4 months, and 5 months, respectively. Various clinicopathological features and prognostic values are associated with different metastatic sites. Understanding these differences may enable targeted pre-treatment assessment of primary mRCC and personalized curative intervention for patients.
format	article
author	Haibin Wei Jia Miao Jianxin Cui Wei Zheng Xinpeng Chen Qi Zhang Feng Liu Zujie Mao Songlin Qiu Dahong Zhang
author_facet	Haibin Wei Jia Miao Jianxin Cui Wei Zheng Xinpeng Chen Qi Zhang Feng Liu Zujie Mao Songlin Qiu Dahong Zhang
author_sort	Haibin Wei
title	The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
title_short	The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
title_full	The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
title_fullStr	The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
title_full_unstemmed	The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database
title_sort	prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the seer database
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/105609fee2274917b962f09aa3a2cae0
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The prognosis and clinicopathological features of different distant metastases patterns in renal cell carcinoma: analysis based on the SEER database

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