Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells

Chromatin neighbourhoods, formed by CTCF, have been proposed to isolate enhancers and their target genes from other regulatory elements. Here, the authors provide evidence that while CTCF binding does regulates mammary-specific super-enhancers, CTCF sites are relatively porous borders.

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Detalles Bibliográficos
Autores principales:	M. Willi, K. H. Yoo, F. Reinisch, T. M. Kuhns, H. K. Lee, C. Wang, L. Hennighausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1057d39f009a4ecb848102da8b5aeb00
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spelling	oai:doaj.org-article:1057d39f009a4ecb848102da8b5aeb002021-12-02T17:06:01ZFacultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells10.1038/ncomms160692041-1723https://doaj.org/article/1057d39f009a4ecb848102da8b5aeb002017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16069https://doaj.org/toc/2041-1723Chromatin neighbourhoods, formed by CTCF, have been proposed to isolate enhancers and their target genes from other regulatory elements. Here, the authors provide evidence that while CTCF binding does regulates mammary-specific super-enhancers, CTCF sites are relatively porous borders.M. WilliK. H. YooF. ReinischT. M. KuhnsH. K. LeeC. WangL. HennighausenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Willi K. H. Yoo F. Reinisch T. M. Kuhns H. K. Lee C. Wang L. Hennighausen Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
description	Chromatin neighbourhoods, formed by CTCF, have been proposed to isolate enhancers and their target genes from other regulatory elements. Here, the authors provide evidence that while CTCF binding does regulates mammary-specific super-enhancers, CTCF sites are relatively porous borders.
format	article
author	M. Willi K. H. Yoo F. Reinisch T. M. Kuhns H. K. Lee C. Wang L. Hennighausen
author_facet	M. Willi K. H. Yoo F. Reinisch T. M. Kuhns H. K. Lee C. Wang L. Hennighausen
author_sort	M. Willi
title	Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
title_short	Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
title_full	Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
title_fullStr	Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
title_full_unstemmed	Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
title_sort	facultative ctcf sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1057d39f009a4ecb848102da8b5aeb00
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Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells

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