Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

Abstract Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flav...

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Autores principales:	Jason Darmadi, Razethy Rahayu Batubara, Sandiego Himawan, Norma Nur Azizah, Hilyatushalihah Kholis Audah, Ade Arsianti, Evi Kurniawaty, Intan Safinar Ismail, Irmanida Batubara, Kholis Abdurachim Audah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1058a2fe491b4ae3a013b7522d453566
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spelling	oai:doaj.org-article:1058a2fe491b4ae3a013b7522d4535662021-12-02T13:18:02ZEvaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug10.1038/s41598-021-85383-32045-2322https://doaj.org/article/1058a2fe491b4ae3a013b7522d4535662021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85383-3https://doaj.org/toc/2045-2322Abstract Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug.Jason DarmadiRazethy Rahayu BatubaraSandiego HimawanNorma Nur AzizahHilyatushalihah Kholis AudahAde ArsiantiEvi KurniawatyIntan Safinar IsmailIrmanida BatubaraKholis Abdurachim AudahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jason Darmadi Razethy Rahayu Batubara Sandiego Himawan Norma Nur Azizah Hilyatushalihah Kholis Audah Ade Arsianti Evi Kurniawaty Intan Safinar Ismail Irmanida Batubara Kholis Abdurachim Audah Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
description	Abstract Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug.
format	article
author	Jason Darmadi Razethy Rahayu Batubara Sandiego Himawan Norma Nur Azizah Hilyatushalihah Kholis Audah Ade Arsianti Evi Kurniawaty Intan Safinar Ismail Irmanida Batubara Kholis Abdurachim Audah
author_facet	Jason Darmadi Razethy Rahayu Batubara Sandiego Himawan Norma Nur Azizah Hilyatushalihah Kholis Audah Ade Arsianti Evi Kurniawaty Intan Safinar Ismail Irmanida Batubara Kholis Abdurachim Audah
author_sort	Jason Darmadi
title	Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
title_short	Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
title_full	Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
title_fullStr	Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
title_full_unstemmed	Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
title_sort	evaluation of indonesian mangrove xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1058a2fe491b4ae3a013b7522d453566
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Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

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