SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS
The article presents the results of studies concerning secretion of cytokines belonging to interleukin 12 family, i.e., IL-12р70, IL-12р40, IL-12р35 and IL-27 in mononuclear blood leukocytes, as well as expression of their specific receptors on T-lymphocytes from tuberculosis patients under the in v...
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2014
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oai:doaj.org-article:105951fc765c46fbaade0f6ae128d4432021-11-18T08:03:44ZSECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2014-3-237-246https://doaj.org/article/105951fc765c46fbaade0f6ae128d4432014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/689https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article presents the results of studies concerning secretion of cytokines belonging to interleukin 12 family, i.e., IL-12р70, IL-12р40, IL-12р35 and IL-27 in mononuclear blood leukocytes, as well as expression of their specific receptors on T-lymphocytes from tuberculosis patients under the in vitro conditions of directed (resp., antigen- and cytokine-mediated) cell induction. In patients with pulmonary TB, we have registered suppression of both spontaneous and BCG-induced secretion of IL-12р70 and IL- 12р35, along with overproduction of IL-12р40 and IL-27. Furthermore, a decrease in relative contents of СD3+gp130+,CD3+IL12Rβ2+ lymphocytes were revealed in the in vitro IL-12/IL-27 induction tests, as well as increased concentration of T-cells with high expression of the inhibitory molecule WSX-1 (CD3+WSX-1+hi). It was shown that the detectable changes are unidirectional in most cases, being dependent on clinical form of the disease and sensitivity of the etiological agent to anti-tuberculosis drugs.I. E. EsimovaO. I. UrazovaV. V. NovitskiyR. R. KhasanovaO. V. FilinyukSPb RAACIarticleinterleukinsil-12il-27interleukin receptorst lymphocytes pulmonary tuberculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 237-246 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
interleukins il-12 il-27 interleukin receptors t lymphocytes pulmonary tuberculosis Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
interleukins il-12 il-27 interleukin receptors t lymphocytes pulmonary tuberculosis Immunologic diseases. Allergy RC581-607 I. E. Esimova O. I. Urazova V. V. Novitskiy R. R. Khasanova O. V. Filinyuk SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS |
| description |
The article presents the results of studies concerning secretion of cytokines belonging to interleukin 12 family, i.e., IL-12р70, IL-12р40, IL-12р35 and IL-27 in mononuclear blood leukocytes, as well as expression of their specific receptors on T-lymphocytes from tuberculosis patients under the in vitro conditions of directed (resp., antigen- and cytokine-mediated) cell induction. In patients with pulmonary TB, we have registered suppression of both spontaneous and BCG-induced secretion of IL-12р70 and IL- 12р35, along with overproduction of IL-12р40 and IL-27. Furthermore, a decrease in relative contents of СD3+gp130+,CD3+IL12Rβ2+ lymphocytes were revealed in the in vitro IL-12/IL-27 induction tests, as well as increased concentration of T-cells with high expression of the inhibitory molecule WSX-1 (CD3+WSX-1+hi). It was shown that the detectable changes are unidirectional in most cases, being dependent on clinical form of the disease and sensitivity of the etiological agent to anti-tuberculosis drugs. |
| format |
article |
| author |
I. E. Esimova O. I. Urazova V. V. Novitskiy R. R. Khasanova O. V. Filinyuk |
| author_facet |
I. E. Esimova O. I. Urazova V. V. Novitskiy R. R. Khasanova O. V. Filinyuk |
| author_sort |
I. E. Esimova |
| title |
SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS |
| title_short |
SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS |
| title_full |
SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS |
| title_fullStr |
SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS |
| title_full_unstemmed |
SECRETION OF IL-12, IL-27 BY MONONUCLEAR LEUKOCYTES AND EXPRESSION OF THEIR RECEPTORS ON T-LYMPHOCYTES IN CONDITIONS OF DIRECTED CELL INDUCTION IN VITRO IN PULMONARY TUBERCULOSIS |
| title_sort |
secretion of il-12, il-27 by mononuclear leukocytes and expression of their receptors on t-lymphocytes in conditions of directed cell induction in vitro in pulmonary tuberculosis |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/105951fc765c46fbaade0f6ae128d443 |
| work_keys_str_mv |
AT ieesimova secretionofil12il27bymononuclearleukocytesandexpressionoftheirreceptorsontlymphocytesinconditionsofdirectedcellinductioninvitroinpulmonarytuberculosis AT oiurazova secretionofil12il27bymononuclearleukocytesandexpressionoftheirreceptorsontlymphocytesinconditionsofdirectedcellinductioninvitroinpulmonarytuberculosis AT vvnovitskiy secretionofil12il27bymononuclearleukocytesandexpressionoftheirreceptorsontlymphocytesinconditionsofdirectedcellinductioninvitroinpulmonarytuberculosis AT rrkhasanova secretionofil12il27bymononuclearleukocytesandexpressionoftheirreceptorsontlymphocytesinconditionsofdirectedcellinductioninvitroinpulmonarytuberculosis AT ovfilinyuk secretionofil12il27bymononuclearleukocytesandexpressionoftheirreceptorsontlymphocytesinconditionsofdirectedcellinductioninvitroinpulmonarytuberculosis |
| _version_ |
1718422396973613056 |