Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making

Abstract Statewide legislation has increased public access to high-potency cannabis flower and concentrates, yet federal restrictions limit researchers’ access to relatively low-potency whole-plant cannabis. The goal of this study was to examine the acute effects of high-potency cannabis on cognitio...

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Autores principales:	Carrie Cuttler, Emily M. LaFrance, Amanda Stueber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/105a1525e95342c4a4778c5886bf7e9c
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spelling	oai:doaj.org-article:105a1525e95342c4a4778c5886bf7e9c2021-12-02T18:18:43ZAcute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making10.1038/s41598-021-93198-52045-2322https://doaj.org/article/105a1525e95342c4a4778c5886bf7e9c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93198-5https://doaj.org/toc/2045-2322Abstract Statewide legislation has increased public access to high-potency cannabis flower and concentrates, yet federal restrictions limit researchers’ access to relatively low-potency whole-plant cannabis. The goal of this study was to examine the acute effects of high-potency cannabis on cognition using a novel methodology. We further sought to compare cognitive effects of high-potency cannabis flower with and without cannabidiol (CBD), as well as cannabis concentrates to cannabis flower. 80 cannabis users were randomly assigned to stay sober or use their funds to purchase one of three high-potency cannabis products: (1) high-potency flower (≥ 20% THC) without CBD, (2) high-potency flower with CBD, (3) high-potency concentrates (≥ 60% THC) with CBD. Participants were observed over Zoom videoconferencing while inhaling their product or remaining sober and then were administered tests of everyday life memory (prospective, source, temporal order, and false memory) and decision making (risky choice framing, consistency in risk perception, resistance to sunk cost, and over/under confidence) over Zoom. High-potency cannabis flower with CBD impaired free recall, high-potency flower without CBD and concentrates had detrimental effects on source memory, and all three products increased susceptibility to false memories. CBD did not offset impairments and concentrates were self-titrated producing comparable intoxication and impairment as flower.Carrie CuttlerEmily M. LaFranceAmanda StueberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carrie Cuttler Emily M. LaFrance Amanda Stueber Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
description	Abstract Statewide legislation has increased public access to high-potency cannabis flower and concentrates, yet federal restrictions limit researchers’ access to relatively low-potency whole-plant cannabis. The goal of this study was to examine the acute effects of high-potency cannabis on cognition using a novel methodology. We further sought to compare cognitive effects of high-potency cannabis flower with and without cannabidiol (CBD), as well as cannabis concentrates to cannabis flower. 80 cannabis users were randomly assigned to stay sober or use their funds to purchase one of three high-potency cannabis products: (1) high-potency flower (≥ 20% THC) without CBD, (2) high-potency flower with CBD, (3) high-potency concentrates (≥ 60% THC) with CBD. Participants were observed over Zoom videoconferencing while inhaling their product or remaining sober and then were administered tests of everyday life memory (prospective, source, temporal order, and false memory) and decision making (risky choice framing, consistency in risk perception, resistance to sunk cost, and over/under confidence) over Zoom. High-potency cannabis flower with CBD impaired free recall, high-potency flower without CBD and concentrates had detrimental effects on source memory, and all three products increased susceptibility to false memories. CBD did not offset impairments and concentrates were self-titrated producing comparable intoxication and impairment as flower.
format	article
author	Carrie Cuttler Emily M. LaFrance Amanda Stueber
author_facet	Carrie Cuttler Emily M. LaFrance Amanda Stueber
author_sort	Carrie Cuttler
title	Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
title_short	Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
title_full	Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
title_fullStr	Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
title_full_unstemmed	Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
title_sort	acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/105a1525e95342c4a4778c5886bf7e9c
work_keys_str_mv	AT carriecuttler acuteeffectsofhighpotencycannabisflowerandcannabisconcentratesoneverydaylifememoryanddecisionmaking AT emilymlafrance acuteeffectsofhighpotencycannabisflowerandcannabisconcentratesoneverydaylifememoryanddecisionmaking AT amandastueber acuteeffectsofhighpotencycannabisflowerandcannabisconcentratesoneverydaylifememoryanddecisionmaking
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Acute effects of high-potency cannabis flower and cannabis concentrates on everyday life memory and decision making

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