Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway

Abstract Systemic transplantation of oxygen−glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. Herein, we analyzed whether or not extracellular vesicles (EVs) derive...

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Bibliographic Details
Main Authors: Lin Zhang, Wei Wei, Xiaoyu Ai, Ertugrul Kilic, Dirk M. Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R. Doeppner
Format: article
Language:EN
Published: Nature Publishing Group 2021
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Online Access:https://doaj.org/article/105c1a6926774a8aa499ce43d7ba73ec
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