The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis
BackgroundAlthough the effect of the LEP G19A (rs2167270) polymorphism on cancers is assumed, the results of its influence have been contradictory. A meta-analysis was conducted to precisely verify the relationships between LEP G19A and the development of digestion-related cancers.MethodsInvestigato...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1061c7063b7243a2bcd06dbed8dd0c842021-11-18T11:43:02ZThe Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis2234-943X10.3389/fonc.2021.754162https://doaj.org/article/1061c7063b7243a2bcd06dbed8dd0c842021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.754162/fullhttps://doaj.org/toc/2234-943XBackgroundAlthough the effect of the LEP G19A (rs2167270) polymorphism on cancers is assumed, the results of its influence have been contradictory. A meta-analysis was conducted to precisely verify the relationships between LEP G19A and the development of digestion-related cancers.MethodsInvestigators systematically searched the literature in PubMed, Embase, and Web of Science and used STATA software 14.0 for the meta−analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the associations. Subgroup analyses stratified by ethnicity, cancer type, and cancer system were further conducted to assess the relationship between the LEP G19A polymorphism and digestion-related cancers.ResultsIn the overall population, we found a significant relationship with overall cancer (allele comparison: OR = 0.921, p = 0.000; dominant comparison: OR = 0.923, p = 0.004; recessive comparison: OR = 0.842, p = 0.000; homozygote model: OR = 0.0843, p = 0.001). In a subgroup analysis conducted by ethnicity, we obtained significant results in Asians (Asian allele comparison: OR = 0.885, p = 0.000; dominant comparison: OR = 0.862, p = 0.000; homozygote model: OR = 0.824, p = 0.039; and heterozygote comparison: OR = 0.868, p = 0.000) but not in Caucasians. In a subgroup analysis conducted by cancer type and cancer system, we obtained significant results that the LEP G19A polymorphism may decrease the risk of colorectal cancer, esophageal cancer, digestive system cancer, and urinary system cancer.ConclusionsThis meta-analysis revealed that the LEP G19A polymorphism may decrease the risk of cancer.Aiqiao ZhangAiqiao ZhangShangren WangFujun ZhangFujun ZhangWei LiWei LiQian LiQian LiXiaoqiang LiuFrontiers Media S.A.articleleptin (LEP)cancerpolymorphismA19Grs2167270Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
leptin (LEP) cancer polymorphism A19G rs2167270 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
leptin (LEP) cancer polymorphism A19G rs2167270 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Aiqiao Zhang Aiqiao Zhang Shangren Wang Fujun Zhang Fujun Zhang Wei Li Wei Li Qian Li Qian Li Xiaoqiang Liu The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis |
| description |
BackgroundAlthough the effect of the LEP G19A (rs2167270) polymorphism on cancers is assumed, the results of its influence have been contradictory. A meta-analysis was conducted to precisely verify the relationships between LEP G19A and the development of digestion-related cancers.MethodsInvestigators systematically searched the literature in PubMed, Embase, and Web of Science and used STATA software 14.0 for the meta−analysis. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the associations. Subgroup analyses stratified by ethnicity, cancer type, and cancer system were further conducted to assess the relationship between the LEP G19A polymorphism and digestion-related cancers.ResultsIn the overall population, we found a significant relationship with overall cancer (allele comparison: OR = 0.921, p = 0.000; dominant comparison: OR = 0.923, p = 0.004; recessive comparison: OR = 0.842, p = 0.000; homozygote model: OR = 0.0843, p = 0.001). In a subgroup analysis conducted by ethnicity, we obtained significant results in Asians (Asian allele comparison: OR = 0.885, p = 0.000; dominant comparison: OR = 0.862, p = 0.000; homozygote model: OR = 0.824, p = 0.039; and heterozygote comparison: OR = 0.868, p = 0.000) but not in Caucasians. In a subgroup analysis conducted by cancer type and cancer system, we obtained significant results that the LEP G19A polymorphism may decrease the risk of colorectal cancer, esophageal cancer, digestive system cancer, and urinary system cancer.ConclusionsThis meta-analysis revealed that the LEP G19A polymorphism may decrease the risk of cancer. |
| format |
article |
| author |
Aiqiao Zhang Aiqiao Zhang Shangren Wang Fujun Zhang Fujun Zhang Wei Li Wei Li Qian Li Qian Li Xiaoqiang Liu |
| author_facet |
Aiqiao Zhang Aiqiao Zhang Shangren Wang Fujun Zhang Fujun Zhang Wei Li Wei Li Qian Li Qian Li Xiaoqiang Liu |
| author_sort |
Aiqiao Zhang |
| title |
The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis |
| title_short |
The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis |
| title_full |
The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis |
| title_fullStr |
The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis |
| title_full_unstemmed |
The Prognosis of Leptin rs2167270 G > A (G19A) Polymorphism in the Risk of Cancer: A Meta-Analysis |
| title_sort |
prognosis of leptin rs2167270 g > a (g19a) polymorphism in the risk of cancer: a meta-analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1061c7063b7243a2bcd06dbed8dd0c84 |
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