Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.

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Autores principales:	Yuheng Shi, Bofeng Yuan, Wenting Zhu, Rui Zhang, Lin Li, Xiaojing Hao, She Chen, Fajian Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1063152fa3d74e488b696ce78d06b044
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spelling	oai:doaj.org-article:1063152fa3d74e488b696ce78d06b0442021-12-02T15:38:56ZUbe2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity10.1038/ncomms151382041-1723https://doaj.org/article/1063152fa3d74e488b696ce78d06b0442017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15138https://doaj.org/toc/2041-1723The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.Yuheng ShiBofeng YuanWenting ZhuRui ZhangLin LiXiaojing HaoShe ChenFajian HouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuheng Shi Bofeng Yuan Wenting Zhu Rui Zhang Lin Li Xiaojing Hao She Chen Fajian Hou Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
description	The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.
format	article
author	Yuheng Shi Bofeng Yuan Wenting Zhu Rui Zhang Lin Li Xiaojing Hao She Chen Fajian Hou
author_facet	Yuheng Shi Bofeng Yuan Wenting Zhu Rui Zhang Lin Li Xiaojing Hao She Chen Fajian Hou
author_sort	Yuheng Shi
title	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
title_short	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
title_full	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
title_fullStr	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
title_full_unstemmed	Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity
title_sort	ube2d3 and ube2n are essential for rig-i-mediated mavs aggregation in antiviral innate immunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1063152fa3d74e488b696ce78d06b044
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Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

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