Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity

The RIG-I-MAVS signalling pathway plays an important role in sensing virus infection. Here the authors identify the ubiquitin-conjugating enzymes Ube2D3 and Ube2N as essential for RIG-I activation and define their roles in mediating MAVS aggregation.

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Autores principales: Yuheng Shi, Bofeng Yuan, Wenting Zhu, Rui Zhang, Lin Li, Xiaojing Hao, She Chen, Fajian Hou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/1063152fa3d74e488b696ce78d06b044
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