N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study

Abstract Few data on clinical characteristics associated with N-terminal pro-brain natriuretic peptide (NT-proBNP) or the clinical value of measuring NT-proBNP in the working population are available. The aim of the present study was to investigate the levels of NT-proBNP and their association with...

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Autores principales:	Atsushi Tanaka, Hisako Yoshida, Atsushi Kawaguchi, Jun-ichi Oyama, Norihiko Kotooka, Shigeru Toyoda, Teruo Inoue, Masafumi Natsuaki, Koichi Node
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10641bf46ddd4f72a82f81e7c819fa07
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spelling	oai:doaj.org-article:10641bf46ddd4f72a82f81e7c819fa072021-12-02T12:32:51ZN-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study10.1038/s41598-017-06090-62045-2322https://doaj.org/article/10641bf46ddd4f72a82f81e7c819fa072017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06090-6https://doaj.org/toc/2045-2322Abstract Few data on clinical characteristics associated with N-terminal pro-brain natriuretic peptide (NT-proBNP) or the clinical value of measuring NT-proBNP in the working population are available. The aim of the present study was to investigate the levels of NT-proBNP and their association with clinical variables in the Japanese general working population by using baseline data from the Uranosaki cohort study. In the study, the plasma concentration of NT-proBNP and some biomarkers were measured in addition to the standard health checkups at the workplace. Questionnaires regarding health-related quality of life (HR-QOL) were also completed. A total of 2140 participants were enrolled in the study. Plasma levels of NT-proBNP were positively associated with age, female sex, systolic blood pressure, pulse pressure, prevalent hypertension, smoking habit, high-density lipoprotein cholesterol (HDL-C), and prevalent proteinuria, and negatively associated with body mass index, lipid profiles except HDL-C, uric acid, renal function, and hemoglobin. Both the plasma concentration of high-molecular weight adiponectin and that of high-sensitivity troponin T were positively and independently associated with NT-proBNP. In addition, the HR-QOL score regarding sleep disorder was independently associated with NT-proBNP. Thus, we have obtained evidence that the plasma NT-proBNP is affected by several clinical variables in the general working population.Atsushi TanakaHisako YoshidaAtsushi KawaguchiJun-ichi OyamaNorihiko KotookaShigeru ToyodaTeruo InoueMasafumi NatsuakiKoichi NodeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsushi Tanaka Hisako Yoshida Atsushi Kawaguchi Jun-ichi Oyama Norihiko Kotooka Shigeru Toyoda Teruo Inoue Masafumi Natsuaki Koichi Node N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
description	Abstract Few data on clinical characteristics associated with N-terminal pro-brain natriuretic peptide (NT-proBNP) or the clinical value of measuring NT-proBNP in the working population are available. The aim of the present study was to investigate the levels of NT-proBNP and their association with clinical variables in the Japanese general working population by using baseline data from the Uranosaki cohort study. In the study, the plasma concentration of NT-proBNP and some biomarkers were measured in addition to the standard health checkups at the workplace. Questionnaires regarding health-related quality of life (HR-QOL) were also completed. A total of 2140 participants were enrolled in the study. Plasma levels of NT-proBNP were positively associated with age, female sex, systolic blood pressure, pulse pressure, prevalent hypertension, smoking habit, high-density lipoprotein cholesterol (HDL-C), and prevalent proteinuria, and negatively associated with body mass index, lipid profiles except HDL-C, uric acid, renal function, and hemoglobin. Both the plasma concentration of high-molecular weight adiponectin and that of high-sensitivity troponin T were positively and independently associated with NT-proBNP. In addition, the HR-QOL score regarding sleep disorder was independently associated with NT-proBNP. Thus, we have obtained evidence that the plasma NT-proBNP is affected by several clinical variables in the general working population.
format	article
author	Atsushi Tanaka Hisako Yoshida Atsushi Kawaguchi Jun-ichi Oyama Norihiko Kotooka Shigeru Toyoda Teruo Inoue Masafumi Natsuaki Koichi Node
author_facet	Atsushi Tanaka Hisako Yoshida Atsushi Kawaguchi Jun-ichi Oyama Norihiko Kotooka Shigeru Toyoda Teruo Inoue Masafumi Natsuaki Koichi Node
author_sort	Atsushi Tanaka
title	N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
title_short	N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
title_full	N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
title_fullStr	N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
title_full_unstemmed	N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
title_sort	n-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the uranosaki cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10641bf46ddd4f72a82f81e7c819fa07
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N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study

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