Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification
Abstract Computed tomography (CT) is a widely used imaging modality. Among the recent technical improvements to increase the range of detection for optimized diagnostic, new devices such as dual energy CT allow elemental discrimination but still remain limited to two energies. Spectral photon-counti...
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2019
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oai:doaj.org-article:106655db334f4c4eb3c375fe5b259c652021-12-02T16:07:54ZHybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification10.1038/s41598-019-48641-z2045-2322https://doaj.org/article/106655db334f4c4eb3c375fe5b259c652019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48641-zhttps://doaj.org/toc/2045-2322Abstract Computed tomography (CT) is a widely used imaging modality. Among the recent technical improvements to increase the range of detection for optimized diagnostic, new devices such as dual energy CT allow elemental discrimination but still remain limited to two energies. Spectral photon-counting CT (SPCCT) is an emerging X-ray imaging technology with a completely new multiple energy detection and high spatial resolution (200 μm). This unique technique allows detection and quantification of a given element thanks to an element-specific increase in X-ray absorption for an energy (K-band) depending on its atomic number. The main contrast media used hitherto are iodine-based compounds but the K-edge of iodine (33.2 keV) is out of the range of detection. Therefore, it is crucial to develop contrast media suitable for this advanced technology. Gadolinium, well known and used element for MRI, possess a K-edge (50.2 keV) well suited for the SPCCT modality. The use of nano-objects instead of molecular entities is pushed by the necessity of high local concentration. In this work, nano-GdF3 is validated on a clinical based prototype, to be used as efficient in vivo contrast media. Beside an extremely high stability, it presents long lasting time in the blood pool allowing perfusion imaging of small animals, without apparent toxicity.Niki HalttunenFrederic LerougeFrederic ChaputMarc VandammeSzilvia KarpatiSalim Si-MohamedMonica SigovanLoic BousselEmmanuel ChereulPhilippe DouekStephane ParolaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) |
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Medicine R Science Q Niki Halttunen Frederic Lerouge Frederic Chaput Marc Vandamme Szilvia Karpati Salim Si-Mohamed Monica Sigovan Loic Boussel Emmanuel Chereul Philippe Douek Stephane Parola Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification |
| description |
Abstract Computed tomography (CT) is a widely used imaging modality. Among the recent technical improvements to increase the range of detection for optimized diagnostic, new devices such as dual energy CT allow elemental discrimination but still remain limited to two energies. Spectral photon-counting CT (SPCCT) is an emerging X-ray imaging technology with a completely new multiple energy detection and high spatial resolution (200 μm). This unique technique allows detection and quantification of a given element thanks to an element-specific increase in X-ray absorption for an energy (K-band) depending on its atomic number. The main contrast media used hitherto are iodine-based compounds but the K-edge of iodine (33.2 keV) is out of the range of detection. Therefore, it is crucial to develop contrast media suitable for this advanced technology. Gadolinium, well known and used element for MRI, possess a K-edge (50.2 keV) well suited for the SPCCT modality. The use of nano-objects instead of molecular entities is pushed by the necessity of high local concentration. In this work, nano-GdF3 is validated on a clinical based prototype, to be used as efficient in vivo contrast media. Beside an extremely high stability, it presents long lasting time in the blood pool allowing perfusion imaging of small animals, without apparent toxicity. |
| format |
article |
| author |
Niki Halttunen Frederic Lerouge Frederic Chaput Marc Vandamme Szilvia Karpati Salim Si-Mohamed Monica Sigovan Loic Boussel Emmanuel Chereul Philippe Douek Stephane Parola |
| author_facet |
Niki Halttunen Frederic Lerouge Frederic Chaput Marc Vandamme Szilvia Karpati Salim Si-Mohamed Monica Sigovan Loic Boussel Emmanuel Chereul Philippe Douek Stephane Parola |
| author_sort |
Niki Halttunen |
| title |
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification |
| title_short |
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification |
| title_full |
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification |
| title_fullStr |
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification |
| title_full_unstemmed |
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification |
| title_sort |
hybrid nano-gdf3 contrast media allows pre-clinical in vivo element-specific k-edge imaging and quantification |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/106655db334f4c4eb3c375fe5b259c65 |
| work_keys_str_mv |
AT nikihalttunen hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT fredericlerouge hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT fredericchaput hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT marcvandamme hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT szilviakarpati hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT salimsimohamed hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT monicasigovan hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT loicboussel hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT emmanuelchereul hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT philippedouek hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification AT stephaneparola hybridnanogdf3contrastmediaallowspreclinicalinvivoelementspecifickedgeimagingandquantification |
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1718384638654676992 |