Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

It is traditionally believed that callosal and non-callosal fates are determined early after a neuron’s birth, and that cortical layer (L) 4 excitatory neurons of the primary somatosensory (S1) barrel cortex project only ipsilaterally. However, here authors demonstrate, using a novel axonal retrotra...

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Autores principales:	N. S. De León Reyes, S. Mederos, I. Varela, L. A. Weiss, G. Perea, M. J. Galazo, M. Nieto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/106cb058e4634e248a4c78643c8fc11a
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spelling	oai:doaj.org-article:106cb058e4634e248a4c78643c8fc11a2021-12-02T14:35:31ZTransient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity10.1038/s41467-019-12495-w2041-1723https://doaj.org/article/106cb058e4634e248a4c78643c8fc11a2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12495-whttps://doaj.org/toc/2041-1723It is traditionally believed that callosal and non-callosal fates are determined early after a neuron’s birth, and that cortical layer (L) 4 excitatory neurons of the primary somatosensory (S1) barrel cortex project only ipsilaterally. However, here authors demonstrate, using a novel axonal retrotracing strategy, that L4 neurons develop transient interhemispheric axons that are refined in an area- and layer-specific manner during postnatal development.N. S. De León ReyesS. MederosI. VarelaL. A. WeissG. PereaM. J. GalazoM. NietoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. S. De León Reyes S. Mederos I. Varela L. A. Weiss G. Perea M. J. Galazo M. Nieto Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
description	It is traditionally believed that callosal and non-callosal fates are determined early after a neuron’s birth, and that cortical layer (L) 4 excitatory neurons of the primary somatosensory (S1) barrel cortex project only ipsilaterally. However, here authors demonstrate, using a novel axonal retrotracing strategy, that L4 neurons develop transient interhemispheric axons that are refined in an area- and layer-specific manner during postnatal development.
format	article
author	N. S. De León Reyes S. Mederos I. Varela L. A. Weiss G. Perea M. J. Galazo M. Nieto
author_facet	N. S. De León Reyes S. Mederos I. Varela L. A. Weiss G. Perea M. J. Galazo M. Nieto
author_sort	N. S. De León Reyes
title	Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_short	Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_full	Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_fullStr	Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_full_unstemmed	Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
title_sort	transient callosal projections of l4 neurons are eliminated for the acquisition of local connectivity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/106cb058e4634e248a4c78643c8fc11a
work_keys_str_mv	AT nsdeleonreyes transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity AT smederos transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity AT ivarela transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity AT laweiss transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity AT gperea transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity AT mjgalazo transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity AT mnieto transientcallosalprojectionsofl4neuronsareeliminatedfortheacquisitionoflocalconnectivity
_version_	1718391114606575616

Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity

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