3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

The brain extracellular matrix (ECM) is altered in brain tumors, but its role in cancer progression and drug sensitivity are difficult to study. Here the authors develop a 3D bioengineered brain tissue model using patient-derived samples and tunable brain-derived ECM to examine the interplay between...

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Autores principales:	Disha Sood, Min Tang-Schomer, Dimitra Pouli, Craig Mizzoni, Nicole Raia, Albert Tai, Knarik Arkun, Julian Wu, Lauren D. Black, Bjorn Scheffler, Irene Georgakoudi, Dennis A. Steindler, David L. Kaplan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1070b5f8d69648f7a27232b3737d6a18
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spelling	oai:doaj.org-article:1070b5f8d69648f7a27232b3737d6a182021-12-02T17:32:56Z3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors10.1038/s41467-019-12420-12041-1723https://doaj.org/article/1070b5f8d69648f7a27232b3737d6a182019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12420-1https://doaj.org/toc/2041-1723The brain extracellular matrix (ECM) is altered in brain tumors, but its role in cancer progression and drug sensitivity are difficult to study. Here the authors develop a 3D bioengineered brain tissue model using patient-derived samples and tunable brain-derived ECM to examine the interplay between cells and the ECM.Disha SoodMin Tang-SchomerDimitra PouliCraig MizzoniNicole RaiaAlbert TaiKnarik ArkunJulian WuLauren D. BlackBjorn SchefflerIrene GeorgakoudiDennis A. SteindlerDavid L. KaplanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Disha Sood Min Tang-Schomer Dimitra Pouli Craig Mizzoni Nicole Raia Albert Tai Knarik Arkun Julian Wu Lauren D. Black Bjorn Scheffler Irene Georgakoudi Dennis A. Steindler David L. Kaplan 3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
description	The brain extracellular matrix (ECM) is altered in brain tumors, but its role in cancer progression and drug sensitivity are difficult to study. Here the authors develop a 3D bioengineered brain tissue model using patient-derived samples and tunable brain-derived ECM to examine the interplay between cells and the ECM.
format	article
author	Disha Sood Min Tang-Schomer Dimitra Pouli Craig Mizzoni Nicole Raia Albert Tai Knarik Arkun Julian Wu Lauren D. Black Bjorn Scheffler Irene Georgakoudi Dennis A. Steindler David L. Kaplan
author_facet	Disha Sood Min Tang-Schomer Dimitra Pouli Craig Mizzoni Nicole Raia Albert Tai Knarik Arkun Julian Wu Lauren D. Black Bjorn Scheffler Irene Georgakoudi Dennis A. Steindler David L. Kaplan
author_sort	Disha Sood
title	3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
title_short	3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
title_full	3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
title_fullStr	3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
title_full_unstemmed	3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
title_sort	3d extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1070b5f8d69648f7a27232b3737d6a18
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3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

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