Effect of vitamin C supplementation on stroke recovery: A case-control study

Meheroz H Rabadi1, Bruce S Kristal2,31Burke Rehabilitation Hospital, an affiliate of Weill Medical College of Cornell Medical College, White Plains, NY, USA; 2Burke Medical Research Institute, an affiliate of Weill Medical College of Cornell Medical College, White Plains, NY, USA; 3Department of Neu...

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Autores principales:	Meheroz H Rabadi, Bruce S Kristal
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/107297dff69c41a1a29c1e7641c61a6a
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spelling	oai:doaj.org-article:107297dff69c41a1a29c1e7641c61a6a2021-12-02T07:34:19ZEffect of vitamin C supplementation on stroke recovery: A case-control study1178-1998https://doaj.org/article/107297dff69c41a1a29c1e7641c61a6a2007-04-01T00:00:00Zhttps://www.dovepress.com/effect-of-vitamin-c-supplementation-on-stroke-recovery-a-case-control--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Meheroz H Rabadi1, Bruce S Kristal2,31Burke Rehabilitation Hospital, an affiliate of Weill Medical College of Cornell Medical College, White Plains, NY, USA; 2Burke Medical Research Institute, an affiliate of Weill Medical College of Cornell Medical College, White Plains, NY, USA; 3Department of Neuroscience, Cornell University Medical College, White Plains, NY, USABackground and purpose: Epidemiological studies have associated increased dietary intake of antioxidants (vitamin C, E, and β-carotene) in preventing and decreasing the extent of ischemic brain injury. The effect of vitamin C supplementation on functional recovery after stroke has not been studied. Method: In this retrospective, case-control study of 23 patients with ischemic stroke taking vitamin C were identified and matched for age, sex, onset to admission, and admission total functional independence measure (TFIM) with 23 patients with ischemic stroke not taking Vitamin C supplementation. Vitamin C 1000 mg daily was prescribed on admission to our unit mainly to patients who were undernourished (defined as significant weight loss and/or 90% or less ideal body weight for age and sex) and those with pressure sores. The outcome measures were: change in the TFIM, FIM-Cognition (FIM-Cog), and FIM-Motor sub-scores, discharge disposition, and length of stay (LOS).Results: The change in TFIM (20 ± 13 standard deviation [SD] vs. 26 ± 6, p = 0.20), FIM-Cog (3 ± 3 SD vs. 4 ± 5, p = 0.41), FIM-Motor (15 ± 11 SD vs. 20 ± 13, p = 0.21) sub-scores were less in the vitamin C treated group, but these differences did not reach statistical significance. Similarly, no significant differences were found in LOS (21 ± 9 SD vs. 23 ± 9, p = 0.59), and discharge disposition (home/institution) (9/10 vs. 13/9, p = 0.60) between the vitamin C and the control groups.Conclusion: This study suggests vitamin C supplementation did not enhance functional recovery in undernourished ischemic stroke patients.Keywords: vitamin C; ischemic stroke; functional recoveryMeheroz H RabadiBruce S KristalDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 147-151 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Meheroz H Rabadi Bruce S Kristal Effect of vitamin C supplementation on stroke recovery: A case-control study
description	Meheroz H Rabadi1, Bruce S Kristal2,31Burke Rehabilitation Hospital, an affiliate of Weill Medical College of Cornell Medical College, White Plains, NY, USA; 2Burke Medical Research Institute, an affiliate of Weill Medical College of Cornell Medical College, White Plains, NY, USA; 3Department of Neuroscience, Cornell University Medical College, White Plains, NY, USABackground and purpose: Epidemiological studies have associated increased dietary intake of antioxidants (vitamin C, E, and β-carotene) in preventing and decreasing the extent of ischemic brain injury. The effect of vitamin C supplementation on functional recovery after stroke has not been studied. Method: In this retrospective, case-control study of 23 patients with ischemic stroke taking vitamin C were identified and matched for age, sex, onset to admission, and admission total functional independence measure (TFIM) with 23 patients with ischemic stroke not taking Vitamin C supplementation. Vitamin C 1000 mg daily was prescribed on admission to our unit mainly to patients who were undernourished (defined as significant weight loss and/or 90% or less ideal body weight for age and sex) and those with pressure sores. The outcome measures were: change in the TFIM, FIM-Cognition (FIM-Cog), and FIM-Motor sub-scores, discharge disposition, and length of stay (LOS).Results: The change in TFIM (20 ± 13 standard deviation [SD] vs. 26 ± 6, p = 0.20), FIM-Cog (3 ± 3 SD vs. 4 ± 5, p = 0.41), FIM-Motor (15 ± 11 SD vs. 20 ± 13, p = 0.21) sub-scores were less in the vitamin C treated group, but these differences did not reach statistical significance. Similarly, no significant differences were found in LOS (21 ± 9 SD vs. 23 ± 9, p = 0.59), and discharge disposition (home/institution) (9/10 vs. 13/9, p = 0.60) between the vitamin C and the control groups.Conclusion: This study suggests vitamin C supplementation did not enhance functional recovery in undernourished ischemic stroke patients.Keywords: vitamin C; ischemic stroke; functional recovery
format	article
author	Meheroz H Rabadi Bruce S Kristal
author_facet	Meheroz H Rabadi Bruce S Kristal
author_sort	Meheroz H Rabadi
title	Effect of vitamin C supplementation on stroke recovery: A case-control study
title_short	Effect of vitamin C supplementation on stroke recovery: A case-control study
title_full	Effect of vitamin C supplementation on stroke recovery: A case-control study
title_fullStr	Effect of vitamin C supplementation on stroke recovery: A case-control study
title_full_unstemmed	Effect of vitamin C supplementation on stroke recovery: A case-control study
title_sort	effect of vitamin c supplementation on stroke recovery: a case-control study
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/107297dff69c41a1a29c1e7641c61a6a
work_keys_str_mv	AT meherozhrabadi effectofvitamincsupplementationonstrokerecoveryacasecontrolstudy AT bruceskristal effectofvitamincsupplementationonstrokerecoveryacasecontrolstudy
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Effect of vitamin C supplementation on stroke recovery: A case-control study

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