Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

Abstract Background Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrosp...

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Autores principales:	Xiaoyu Wang, Junjun Yang, Xirun Wan, Fengzhi Feng, Jun Zhao, Tong Ren, Yang Xiang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cervical choriocarcinoma Clinical features Diagnosis Gestational trophoblastic neoplasia Treatment Medicine R
Acceso en línea:	https://doaj.org/article/1074192fb2e7478d866b3d80b25388a3
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spelling	oai:doaj.org-article:1074192fb2e7478d866b3d80b25388a32021-11-21T12:26:07ZIdentification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review10.1186/s13023-021-02111-w1750-1172https://doaj.org/article/1074192fb2e7478d866b3d80b25388a32021-11-01T00:00:00Zhttps://doi.org/10.1186/s13023-021-02111-whttps://doaj.org/toc/1750-1172Abstract Background Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies. Results Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%). Conclusions Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.Xiaoyu WangJunjun YangXirun WanFengzhi FengJun ZhaoTong RenYang XiangBMCarticleCervical choriocarcinomaClinical featuresDiagnosisGestational trophoblastic neoplasiaTreatmentMedicineRENOrphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical choriocarcinoma Clinical features Diagnosis Gestational trophoblastic neoplasia Treatment Medicine R
spellingShingle	Cervical choriocarcinoma Clinical features Diagnosis Gestational trophoblastic neoplasia Treatment Medicine R Xiaoyu Wang Junjun Yang Xirun Wan Fengzhi Feng Jun Zhao Tong Ren Yang Xiang Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
description	Abstract Background Primary cervical gestational trophoblastic neoplasias (GTNs) are extremely rare ectopic GTNs. Such lesions are difficult to diagnose clinically because of their rarity, with abnormal vaginal bleeding of a non-specific cause being the most common symptom. To that end, this retrospective study aimed to identify the clinical characteristics of cervical GTN and to explore diagnostic and therapeutic strategies. Results Thirteen patients diagnosed with primary cervical GTN at the Department of Gynecology, Peking Union Medical College Hospital, Beijing, China, between June 1, 1988 and May 31, 2020 were included in the study. All patients had irregular vaginal bleeding, including six who presented with massive bleeding. Seven patients (53.8%) were initially misdiagnosed with a cervical pregnancy. All patients received chemotherapy; 11 (84.6%) also underwent hysterectomy because of chemoresistant lesions or uncontrolled bleeding. All patients achieved complete remission; however, two women (15.4%) experienced a relapse during the median follow-up period of 35 months. A comprehensive review of English-language literature published between 1980 and 2020 identified 22 case reports encompassing 27 patients. The definitive diagnosis was achieved via pathology in 26 of them (96.3%), and hysterectomy was performed in 21 (77.8%). Conclusions Owing to its rarity and nonspecific symptoms, the diagnosis of primary cervical GTN is challenging and often relies on pathology. The combination of chemotherapy and hysterectomy is the main therapeutic strategy for this disease.
format	article
author	Xiaoyu Wang Junjun Yang Xirun Wan Fengzhi Feng Jun Zhao Tong Ren Yang Xiang
author_facet	Xiaoyu Wang Junjun Yang Xirun Wan Fengzhi Feng Jun Zhao Tong Ren Yang Xiang
author_sort	Xiaoyu Wang
title	Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
title_short	Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
title_full	Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
title_fullStr	Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
title_full_unstemmed	Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
title_sort	identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1074192fb2e7478d866b3d80b25388a3
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Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review

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