The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions

Abstract The ventromedial and dorsolateral prefrontal cortex are two major prefrontal regions that usually interact in serving different cognitive functions. On the other hand, these regions are also involved in cognitive processing of emotions but their contribution to emotional processing is not w...

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Autores principales:	Vahid Nejati, Reyhaneh Majdi, Mohammad Ali Salehinejad, Michael A. Nitsche
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10747cd896e8483c958c49888dc0435e
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spelling	oai:doaj.org-article:10747cd896e8483c958c49888dc0435e2021-12-02T13:51:16ZThe role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions10.1038/s41598-021-81454-72045-2322https://doaj.org/article/10747cd896e8483c958c49888dc0435e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81454-7https://doaj.org/toc/2045-2322Abstract The ventromedial and dorsolateral prefrontal cortex are two major prefrontal regions that usually interact in serving different cognitive functions. On the other hand, these regions are also involved in cognitive processing of emotions but their contribution to emotional processing is not well-studied. In the present study, we investigated the role of these regions in three dimensions (valence, arousal and dominance) of emotional processing of stimuli via ratings of visual stimuli performed by the study participants on these dimensions. Twenty- two healthy adult participants (mean age 25.21 ± 3.84 years) were recruited and received anodal and sham transcranial direct current stimulation (tDCS) (1.5 mA, 15 min) over the dorsolateral prefrontal cortex (dlPFC) and and ventromedial prefrontal cortex (vmPFC) in three separate sessions with an at least 72-h interval. During stimulation, participants underwent an emotional task in each stimulation condition. The task included 100 visual stimuli and participants were asked to rate them with respect to valence, arousal, and dominance. Results show a significant effect of stimulation condition on different aspects of emotional processing. Specifically, anodal tDCS over the dlPFC significantly reduced valence attribution for positive pictures. In contrast, anodal tDCS over the vmPFC significantly reduced arousal ratings. Dominance ratings were not affected by the intervention. Our results suggest that the dlPFC is involved in control and regulation of valence of emotional experiences, while the vmPFC might be involved in the extinction of arousal caused by emotional stimuli. Our findings implicate dimension-specific processing of emotions by different prefrontal areas which has implications for disorders characterized by emotional disturbances such as anxiety or mood disorders.Vahid NejatiReyhaneh MajdiMohammad Ali SalehinejadMichael A. NitscheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vahid Nejati Reyhaneh Majdi Mohammad Ali Salehinejad Michael A. Nitsche The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
description	Abstract The ventromedial and dorsolateral prefrontal cortex are two major prefrontal regions that usually interact in serving different cognitive functions. On the other hand, these regions are also involved in cognitive processing of emotions but their contribution to emotional processing is not well-studied. In the present study, we investigated the role of these regions in three dimensions (valence, arousal and dominance) of emotional processing of stimuli via ratings of visual stimuli performed by the study participants on these dimensions. Twenty- two healthy adult participants (mean age 25.21 ± 3.84 years) were recruited and received anodal and sham transcranial direct current stimulation (tDCS) (1.5 mA, 15 min) over the dorsolateral prefrontal cortex (dlPFC) and and ventromedial prefrontal cortex (vmPFC) in three separate sessions with an at least 72-h interval. During stimulation, participants underwent an emotional task in each stimulation condition. The task included 100 visual stimuli and participants were asked to rate them with respect to valence, arousal, and dominance. Results show a significant effect of stimulation condition on different aspects of emotional processing. Specifically, anodal tDCS over the dlPFC significantly reduced valence attribution for positive pictures. In contrast, anodal tDCS over the vmPFC significantly reduced arousal ratings. Dominance ratings were not affected by the intervention. Our results suggest that the dlPFC is involved in control and regulation of valence of emotional experiences, while the vmPFC might be involved in the extinction of arousal caused by emotional stimuli. Our findings implicate dimension-specific processing of emotions by different prefrontal areas which has implications for disorders characterized by emotional disturbances such as anxiety or mood disorders.
format	article
author	Vahid Nejati Reyhaneh Majdi Mohammad Ali Salehinejad Michael A. Nitsche
author_facet	Vahid Nejati Reyhaneh Majdi Mohammad Ali Salehinejad Michael A. Nitsche
author_sort	Vahid Nejati
title	The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
title_short	The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
title_full	The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
title_fullStr	The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
title_full_unstemmed	The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
title_sort	role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10747cd896e8483c958c49888dc0435e
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The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions

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