Factors associated to duration of hepatitis a outbreaks: implications for control.
Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was...
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2012
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oai:doaj.org-article:1078fd09f1d44cd8b05ab6c232bf538b2021-11-18T07:28:06ZFactors associated to duration of hepatitis a outbreaks: implications for control.1932-620310.1371/journal.pone.0031339https://doaj.org/article/1078fd09f1d44cd8b05ab6c232bf538b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22355358/?tool=EBIhttps://doaj.org/toc/1932-6203Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 10(5) persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94-0.98) and school setting (OR = 0.39; 95% CI: 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration.Nuria TornerSonia BronerAna MartinezCecilia TortajadaPatricia Garcia de OlallaIrene BarrabeigMariaRosa SalaNeus CampsSofia MinguellJosep AlvarezGloria FerrúsRoser TorraPere GodoyAngela DominguezHepatitis A Surveillance Group of Catalonia, SpainPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31339 (2012) |
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Medicine R Science Q |
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Medicine R Science Q Nuria Torner Sonia Broner Ana Martinez Cecilia Tortajada Patricia Garcia de Olalla Irene Barrabeig MariaRosa Sala Neus Camps Sofia Minguell Josep Alvarez Gloria Ferrús Roser Torra Pere Godoy Angela Dominguez Hepatitis A Surveillance Group of Catalonia, Spain Factors associated to duration of hepatitis a outbreaks: implications for control. |
| description |
Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 10(5) persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94-0.98) and school setting (OR = 0.39; 95% CI: 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration. |
| format |
article |
| author |
Nuria Torner Sonia Broner Ana Martinez Cecilia Tortajada Patricia Garcia de Olalla Irene Barrabeig MariaRosa Sala Neus Camps Sofia Minguell Josep Alvarez Gloria Ferrús Roser Torra Pere Godoy Angela Dominguez Hepatitis A Surveillance Group of Catalonia, Spain |
| author_facet |
Nuria Torner Sonia Broner Ana Martinez Cecilia Tortajada Patricia Garcia de Olalla Irene Barrabeig MariaRosa Sala Neus Camps Sofia Minguell Josep Alvarez Gloria Ferrús Roser Torra Pere Godoy Angela Dominguez Hepatitis A Surveillance Group of Catalonia, Spain |
| author_sort |
Nuria Torner |
| title |
Factors associated to duration of hepatitis a outbreaks: implications for control. |
| title_short |
Factors associated to duration of hepatitis a outbreaks: implications for control. |
| title_full |
Factors associated to duration of hepatitis a outbreaks: implications for control. |
| title_fullStr |
Factors associated to duration of hepatitis a outbreaks: implications for control. |
| title_full_unstemmed |
Factors associated to duration of hepatitis a outbreaks: implications for control. |
| title_sort |
factors associated to duration of hepatitis a outbreaks: implications for control. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/1078fd09f1d44cd8b05ab6c232bf538b |
| work_keys_str_mv |
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